Employees – University of Copenhagen

Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. 2014
  2. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / Morris, Lindsey C; Nance, Kellie D; Gentry, Patrick R; Days, Emily L; Weaver, C David; Niswender, Colleen M; Thompson, Analisa D; Jones, Carrie K; Locuson, Chuck W; Morrison, Ryan D; Daniels, J Scott; Niswender, Kevin D; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 10192-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure : 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Noetzel, Meredith J; Cho, Hyekyung P; Lamsal, Atin; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 18, 25.09.2014, p. 7804-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381) : a novel molecular probe. / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 9, No. 8, 08.2014, p. 1677-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. / Foster, Daniel J; Gentry, Patrick R; Lizardi-Ortiz, Jose E; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Sulzer, David; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey.

    In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, No. 9, 26.02.2014, p. 3253-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Drugs for allosteric sites on receptors. / Wenthur, Cody J; Gentry, Patrick R; Mathews, Thomas P; Lindsley, Craig W.

    In: Annual Review of Pharmacology and Toxicology, Vol. 54, 2014, p. 165-84.

    Research output: Contribution to journalReviewResearchpeer-review

  7. 2013
  8. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 22, 27.11.2013, p. 9351-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Discovery of ML326 : The first sub-micromolar, selective M5 PAM. / Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 10, 15.05.2013, p. 2996-3000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137 : the continued optimization of an MLPCN probe molecule. / Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 6, 15.03.2013, p. 1860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137 : continued optimization of an MLPCN probe molecule. / Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 2, 15.01.2013, p. 412-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

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