Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). / Williams, Richard; Johnson, Kari A; Gentry, Patrick R; Niswender, Colleen M; Weaver, Charles D; Conn, P Jeffrey; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 17, 01.09.2009, p. 4967-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Drugs for allosteric sites on receptors. / Wenthur, Cody J; Gentry, Patrick R; Mathews, Thomas P; Lindsley, Craig W.

    In: Annual Review of Pharmacology and Toxicology, Vol. 54, 2014, p. 165-84.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137 : the continued optimization of an MLPCN probe molecule. / Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 6, 15.03.2013, p. 1860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist. / Nøhr, Anne Cathrine; Shehata, Mohamed A; Palmer, Daniel; Pokhrel, Rina; Vallianou, Maria; Foster, Simon R; Gentry, Patrick R; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Scientific Reports, Vol. 9, No. 1, 07.03.2019, p. 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / Morris, Lindsey C; Nance, Kellie D; Gentry, Patrick R; Days, Emily L; Weaver, C David; Niswender, Colleen M; Thompson, Analisa D; Jones, Carrie K; Locuson, Chuck W; Morrison, Ryan D; Daniels, J Scott; Niswender, Kevin D; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 10192-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137 : continued optimization of an MLPCN probe molecule. / Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 2, 15.01.2013, p. 412-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Further optimization of the M5 NAM MLPCN probe ML375 : tactics and challenges. / Kurata, Haruto; Gentry, Patrick R; Kokubo, Masaya; Cho, Hyekyung P; Bridges, Thomas M; Niswender, Colleen M; Byers, Frank W; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 3, 01.02.2015, p. 690-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor. / Kennedy, J Phillip; Bridges, Thomas M; Gentry, Patrick R; Brogan, John T; Kane, Alexander S; Jones, Carrie K; Brady, Ashley E; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 4, No. 10, 10.2009, p. 1600-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. / Hao, Jijun; Ho, Joshua N; Lewis, Jana A; Karim, Kaleh A; Daniels, R Nathan; Gentry, Patrick R; Hopkins, Corey R; Lindsley, Craig W; Hong, Charles C.

    In: ACS chemical biology, Vol. 5, No. 2, 19.02.2010, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. / Gogliotti, Rocco D; Engers, Darren W; Garcia-Barrantes, Pedro M; Panarese, Joseph D; Gentry, Patrick R; Blobaum, Anna L; Morrison, Ryan D; Daniels, J Scott; Thompson, Analisa D; Jones, Carrie K; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 12, 15.06.2016, p. 2915-2919.

    Research output: Contribution to journalJournal articleResearchpeer-review

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