Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. 2014
  2. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Drugs for allosteric sites on receptors

    Wenthur, C. J., Gentry, Patrick Ryan, Mathews, T. P. & Lindsley, C. W., 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 165-84 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  4. 2013
  5. Discovery of ML326: The first sub-micromolar, selective M5 PAM

    Gentry, Patrick Ryan, Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 15 May 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 10, p. 2996-3000 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9351-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

    Melancon, B. J., Poslusney, M. S., Gentry, Patrick Ryan, Tarr, J. C., Sheffler, D. J., Mattmann, M. E., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Jan 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 2, p. 412-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

    Poslusney, M. S., Melancon, B. J., Gentry, Patrick Ryan, Sheffler, D. J., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Mar 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 6, p. 1860-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2012
  10. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction

    Conn, P. J., Lindsley, C. W., Hopkins, C. R., Weaver, D., Niswender, C. M., Engers, D. W., Gentry, Patrick Ryan, Cheung, Y., Salovich, J. & Gogliotti, R. D., 27 Sep 2012, Patent No. US20120245153A1, 4 Sep 2010

    Research output: Patent

  11. 2010
  12. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM

    Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, Patrick Ryan, Hopkins, C. R., Conn, P. J. & Lindsley, C. W., 15 Jan 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 2, p. 558-62 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

    Bridges, T. M., Phillip Kennedy, J., Noetzel, M. J., Breininger, M. L., Gentry, Patrick Ryan, Conn, P. J. & Lindsley, C. W., 15 Mar 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 6, p. 1972-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

    Engers, D. W., Gentry, Patrick Ryan, Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., 1 Sep 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 17, p. 5175-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 172786299