Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

    Brady, A. E., Jones, C. K., Bridges, T. M., Kennedy, J. P., Thompson, A. D., Heiman, J. U., Breininger, M. L., Gentry, Patrick Ryan, Yin, H., Jadhav, S. B., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Dec 2008, In : The Journal of Pharmacology and Experimental Therapeutics. 327, 3, p. 941-53 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM

    Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, Patrick Ryan, Hopkins, C. R., Conn, P. J. & Lindsley, C. W., 15 Jan 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 2, p. 558-62 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

    Bridges, T. M., Phillip Kennedy, J., Noetzel, M. J., Breininger, M. L., Gentry, Patrick Ryan, Conn, P. J. & Lindsley, C. W., 15 Mar 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 6, p. 1972-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

    Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Discovery of ML326: The first sub-micromolar, selective M5 PAM

    Gentry, Patrick Ryan, Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 15 May 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 10, p. 2996-3000 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9351-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

    Bridges, T. M., Marlo, J. E., Niswender, C. M., Jones, C. K., Jadhav, S. B., Gentry, Patrick Ryan, Plumley, H. C., Weaver, C. D., Conn, P. J. & Lindsley, C. W., 11 Jun 2009, In : Journal of Medicinal Chemistry. 52, 11, p. 3445-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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