Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. 2008
  2. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

    Brady, A. E., Jones, C. K., Bridges, T. M., Kennedy, J. P., Thompson, A. D., Heiman, J. U., Breininger, M. L., Gentry, Patrick Ryan, Yin, H., Jadhav, S. B., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Dec 2008, In : The Journal of Pharmacology and Experimental Therapeutics. 327, 3, p. 941-53 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

    Bridges, T. M., Brady, A. E., Kennedy, J. P., Daniels, R. N., Miller, N. R., Kim, K., Breininger, M. L., Gentry, Patrick Ryan, Brogan, J. T., Jones, C. K., Conn, P. J. & Lindsley, C. W., 15 Oct 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 20, p. 5439-42 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2009
  5. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

    Bridges, T. M., Marlo, J. E., Niswender, C. M., Jones, C. K., Jadhav, S. B., Gentry, Patrick Ryan, Plumley, H. C., Weaver, C. D., Conn, P. J. & Lindsley, C. W., 11 Jun 2009, In : Journal of Medicinal Chemistry. 52, 11, p. 3445-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

    Kennedy, J. P., Bridges, T. M., Gentry, Patrick Ryan, Brogan, J. T., Kane, A. S., Jones, C. K., Brady, A. E., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Oct 2009, In : ChemMedChem. 4, 10, p. 1600-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

    Williams, R., Johnson, K. A., Gentry, Patrick Ryan, Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., 1 Sep 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 17, p. 4967-70 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2010
  9. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM

    Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, Patrick Ryan, Hopkins, C. R., Conn, P. J. & Lindsley, C. W., 15 Jan 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 2, p. 558-62 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

    Bridges, T. M., Phillip Kennedy, J., Noetzel, M. J., Breininger, M. L., Gentry, Patrick Ryan, Conn, P. J. & Lindsley, C. W., 15 Mar 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 6, p. 1972-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

    Engers, D. W., Gentry, Patrick Ryan, Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., 1 Sep 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 17, p. 5175-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

    Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, Patrick Ryan, Hopkins, C. R., Lindsley, C. W. & Hong, C. C., 19 Feb 2010, In : ACS chemical biology. 5, 2, p. 245-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2012
  14. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction

    Conn, P. J., Lindsley, C. W., Hopkins, C. R., Weaver, D., Niswender, C. M., Engers, D. W., Gentry, Patrick Ryan, Cheung, Y., Salovich, J. & Gogliotti, R. D., 27 Sep 2012, Patent No. US20120245153A1, 4 Sep 2010

    Research output: Patent

  15. 2013
  16. Discovery of ML326: The first sub-micromolar, selective M5 PAM

    Gentry, Patrick Ryan, Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 15 May 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 10, p. 2996-3000 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9351-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

    Melancon, B. J., Poslusney, M. S., Gentry, Patrick Ryan, Tarr, J. C., Sheffler, D. J., Mattmann, M. E., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Jan 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 2, p. 412-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

    Poslusney, M. S., Melancon, B. J., Gentry, Patrick Ryan, Sheffler, D. J., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Mar 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 6, p. 1860-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2014
  21. M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location

    Foster, D. J., Gentry, Patrick Ryan, Lizardi-Ortiz, J. E., Bridges, T. M., Wood, M. R., Niswender, C. M., Sulzer, D., Lindsley, C. W., Xiang, Z. & Conn, P. J., 26 Feb 2014, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 9, p. 3253-62 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., Daniels, J. S., Wood, M. R., Conn, P. J. & Lindsley, C. W., Aug 2014, In : ChemMedChem. 9, 8, p. 1677-82 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Drugs for allosteric sites on receptors

    Wenthur, C. J., Gentry, Patrick Ryan, Mathews, T. P. & Lindsley, C. W., 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 165-84 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. 2015
  27. Novel Allosteric Modulators of G Protein-coupled Receptors

    Gentry, Patrick Ryan, Sexton, P. M. & Christopoulos, A., 7 Aug 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-88 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges

    Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2016
  30. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

    Berizzi, A. E., Gentry, Patrick Ryan, Rueda, P., Den Hoedt, S., Sexton, P. M., Langmead, C. J. & Christopoulos, A., Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2018
  33. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

    Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2019
  35. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist

    Nøhr, A. C., Shehata, Mohamed A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, Patrick Ryan, Gloriam, David E. & Bräuner-Osborne, Hans, 7 Mar 2019, In : Scientific Reports. 9, 1, 10 p., 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 172786299