Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold. / Bender, Aaron M; Cho, Hyekyung P; Nance, Kellie D; Lingenfelter, Kaelyn S; Luscombe, Vincent B; Gentry, Patrick R; Voigtritter, Karl; Berizzi, Alice E; Sexton, Patrick M; Langmead, Christopher J; Christopoulos, Arthur; Locuson, Charles W; Bridges, Thomas M; Chang, Sichen; O'Neill, Jordan C; Zhan, Xiaoyan; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ACS Chemical Neuroscience, Vol. 9, No. 7, 18.07.2018, p. 1572-1581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators. / Berizzi, Alice E; Gentry, Patrick R; Rueda, Patricia; Den Hoedt, Sandra; Sexton, Patrick M; Langmead, Christopher J; Christopoulos, Arthur.

    In: Molecular Pharmacology, Vol. 90, No. 4, 10.2016, p. 427-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. / Brady, Ashley E; Jones, Carrie K; Bridges, Thomas M; Kennedy, J Phillip; Thompson, Analisa D; Heiman, Justin U; Breininger, Micah L; Gentry, Patrick R; Yin, Huiyong; Jadhav, Satyawan B; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 327, No. 3, 12.2008, p. 941-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I : Development of the first highly selective M(5) PAM. / Bridges, Thomas M; Kennedy, J Phillip; Cho, Hyekyung P; Breininger, Micah L; Gentry, Patrick R; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 2, 15.01.2010, p. 558-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II : development of a potent and highly selective M1 PAM. / Bridges, Thomas M; Phillip Kennedy, J; Noetzel, Meredith J; Breininger, Micah L; Gentry, Patrick R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 6, 15.03.2010, p. 1972-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. / Bridges, Thomas M; Marlo, Joy E; Niswender, Colleen M; Jones, Carrie K; Jadhav, Satyawan B; Gentry, Patrick R; Plumley, Hyekyung C; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 11, 11.06.2009, p. 3445-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I : Exploration of alternative benzyl and privileged structure moieties. / Bridges, Thomas M; Brady, Ashley E; Kennedy, J Phillip; Daniels, R Nathan; Miller, Nicole R; Kim, Kwango; Breininger, Micah L; Gentry, Patrick R; Brogan, John T; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5439-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction. / Conn, P Jeffrey (Inventor); Lindsley, Craig W (Inventor); Hopkins, Corey R (Inventor); Weaver, David (Inventor); Niswender, Colleen M (Inventor); Engers, Darren W (Inventor); Gentry, Patrick Ryan (Inventor); Cheung, Yiu-Yin (Inventor); Salovich, James (Inventor); Gogliotti, Rocco D (Inventor).

    Patent No.: US20120245153A1. Sep 04, 2010.

    Research output: PatentResearch

  9. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). / Engers, Darren W; Gentry, Patrick R; Williams, Richard; Bolinger, Julie D; Weaver, C David; Menon, Usha N; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 17, 01.09.2010, p. 5175-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. / Foster, Daniel J; Gentry, Patrick R; Lizardi-Ortiz, Jose E; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Sulzer, David; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey.

    In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, No. 9, 26.02.2014, p. 3253-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

Previous 1 2 3 Next

ID: 172786299