Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

    Williams, R., Johnson, K. A., Gentry, Patrick Ryan, Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., 1 Sep 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 17, p. 4967-70 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Drugs for allosteric sites on receptors

    Wenthur, C. J., Gentry, Patrick Ryan, Mathews, T. P. & Lindsley, C. W., 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 165-84 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

    Poslusney, M. S., Melancon, B. J., Gentry, Patrick Ryan, Sheffler, D. J., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Mar 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 6, p. 1860-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist

    Nøhr, A. C., Shehata, Mohamed A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, Patrick Ryan, Gloriam, David E. & Bräuner-Osborne, Hans, 7 Mar 2019, In : Scientific Reports. 9, 1, p. 3802

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

    Melancon, B. J., Poslusney, M. S., Gentry, Patrick Ryan, Tarr, J. C., Sheffler, D. J., Mattmann, M. E., Bridges, T. M., Utley, T. J., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Wood, M. R., 15 Jan 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 2, p. 412-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges

    Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

    Kennedy, J. P., Bridges, T. M., Gentry, Patrick Ryan, Brogan, J. T., Kane, A. S., Jones, C. K., Brady, A. E., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Oct 2009, In : ChemMedChem. 4, 10, p. 1600-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

    Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, Patrick Ryan, Hopkins, C. R., Lindsley, C. W. & Hong, C. C., 19 Feb 2010, In : ACS chemical biology. 5, 2, p. 245-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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