Patrick Ryan Gentry

Patrick Ryan Gentry

Assistant professor


  1. 2008
  2. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

    Bridges, T. M., Brady, A. E., Kennedy, J. P., Daniels, R. N., Miller, N. R., Kim, K., Breininger, M. L., Gentry, Patrick Ryan, Brogan, J. T., Jones, C. K., Conn, P. J. & Lindsley, C. W., 15 Oct 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 20, p. 5439-42 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

    Brady, A. E., Jones, C. K., Bridges, T. M., Kennedy, J. P., Thompson, A. D., Heiman, J. U., Breininger, M. L., Gentry, Patrick Ryan, Yin, H., Jadhav, S. B., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Dec 2008, In : The Journal of Pharmacology and Experimental Therapeutics. 327, 3, p. 941-53 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2009
  5. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

    Bridges, T. M., Marlo, J. E., Niswender, C. M., Jones, C. K., Jadhav, S. B., Gentry, Patrick Ryan, Plumley, H. C., Weaver, C. D., Conn, P. J. & Lindsley, C. W., 11 Jun 2009, In : Journal of Medicinal Chemistry. 52, 11, p. 3445-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

    Williams, R., Johnson, K. A., Gentry, Patrick Ryan, Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Hopkins, C. R., 1 Sep 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 17, p. 4967-70 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

    Kennedy, J. P., Bridges, T. M., Gentry, Patrick Ryan, Brogan, J. T., Kane, A. S., Jones, C. K., Brady, A. E., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Oct 2009, In : ChemMedChem. 4, 10, p. 1600-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2010
  9. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM

    Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, Patrick Ryan, Hopkins, C. R., Conn, P. J. & Lindsley, C. W., 15 Jan 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 2, p. 558-62 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

    Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, Patrick Ryan, Hopkins, C. R., Lindsley, C. W. & Hong, C. C., 19 Feb 2010, In : ACS chemical biology. 5, 2, p. 245-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

    Bridges, T. M., Phillip Kennedy, J., Noetzel, M. J., Breininger, M. L., Gentry, Patrick Ryan, Conn, P. J. & Lindsley, C. W., 15 Mar 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 6, p. 1972-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

    Engers, D. W., Gentry, Patrick Ryan, Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., 1 Sep 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 17, p. 5175-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2012
  14. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction

    Conn, P. J., Lindsley, C. W., Hopkins, C. R., Weaver, D., Niswender, C. M., Engers, D. W., Gentry, Patrick Ryan, Cheung, Y., Salovich, J. & Gogliotti, R. D., 27 Sep 2012, Patent No. US20120245153A1, 4 Sep 2010

    Research output: Patent

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