Patrick Ryan Gentry

Patrick Ryan Gentry

Assistant professor


  1. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

    Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

    Berizzi, A. E., Gentry, Patrick Ryan, Rueda, P., Den Hoedt, S., Sexton, P. M., Langmead, C. J. & Christopoulos, A., Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM

    Bridges, T. M., Kennedy, J. P., Cho, H. P., Breininger, M. L., Gentry, Patrick Ryan, Hopkins, C. R., Conn, P. J. & Lindsley, C. W., 15 Jan 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 2, p. 558-62 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

    Bridges, T. M., Phillip Kennedy, J., Noetzel, M. J., Breininger, M. L., Gentry, Patrick Ryan, Conn, P. J. & Lindsley, C. W., 15 Mar 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 6, p. 1972-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

    Bridges, T. M., Marlo, J. E., Niswender, C. M., Jones, C. K., Jadhav, S. B., Gentry, Patrick Ryan, Plumley, H. C., Weaver, C. D., Conn, P. J. & Lindsley, C. W., 11 Jun 2009, In : Journal of Medicinal Chemistry. 52, 11, p. 3445-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction

    Conn, P. J., Lindsley, C. W., Hopkins, C. R., Weaver, D., Niswender, C. M., Engers, D. W., Gentry, Patrick Ryan, Cheung, Y., Salovich, J. & Gogliotti, R. D., 27 Sep 2012, Patent No. US20120245153A1, 4 Sep 2010

    Research output: Patent

  7. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

    Engers, D. W., Gentry, Patrick Ryan, Williams, R., Bolinger, J. D., Weaver, C. D., Menon, U. N., Conn, P. J., Lindsley, C. W., Niswender, C. M. & Hopkins, C. R., 1 Sep 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 17, p. 5175-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location

    Foster, D. J., Gentry, Patrick Ryan, Lizardi-Ortiz, J. E., Bridges, T. M., Wood, M. R., Niswender, C. M., Sulzer, D., Lindsley, C. W., Xiang, Z. & Conn, P. J., 26 Feb 2014, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 9, p. 3253-62 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Discovery of ML326: The first sub-micromolar, selective M5 PAM

    Gentry, Patrick Ryan, Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 15 May 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 10, p. 2996-3000 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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