Tommy Nørskov Johansen

Tommy Nørskov Johansen

Associate Professor / Head of Studies


  1. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. / Ahmadian, H; Nielsen, B; Bräuner-Osborne, Hans; Johansen, T N; Stensbøl, T B; Sløk, F A; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 40, No. 22, 24.10.1997, p. 3700-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors. / Bräuner-Osborne, Hans; Nielsen, B; Stensbøl, T B; Johansen, T N; Skjaerbaek, N; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 335, No. 2-3, 24.09.1997, p. R1-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2. / Bräuner-Osborne, Hans; Hermit, M B; Nielsen, B; Krogsgaard-Larsen, P; Johansen, T N.

    In: European Journal of Pharmacology, Vol. 406, No. 1, 06.10.2000, p. 41-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands. / Bunch, L; Johansen, T H; Bräuner-Osborne, Hans; Stensbøl, T B; Johansen, T N; Krogsgaard-Larsen, P; Madsen, U.

    In: Bioorganic & Medicinal Chemistry, Vol. 9, No. 4, 04.2001, p. 875-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. / Falch, Erik; Brehm, Lotte; Mikkelsen, Ivan; Johansen, Tommy Nørskov; Skjærbæk, Niels; Nielsen, Birgitte; Stensbøl, Tine B.; Ebert, Bjarke; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 41, 1998, p. 2513-2523.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. / Jensen, Anders A.; Mosbacher, Johannes; Elg, Susanne; Lingenhoehl, Kurt; Lohmann, Tania; Johansen, Tommy N; Abrahamsen, Bjarke; Mattsson, Jan; Lehmann, Anders; Bettler, Bernhard; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 61, No. 6, 2002, p. 1377-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. / Jensen, Anders A.; Christesen, Thomas; Bølcho, Ulrik; Greenwood, Jeremy R; Postorino, Giovanna; Vogensen, Stine B; Johansen, Tommy N; Egebjerg, Jan; Bräuner-Osborne, Hans; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 17, 2007, p. 4177-4185.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. / Johansen, T N; Ebert, B; Bräuner-Osborne, Hans; Didriksen, M; Christensen, I T; Søby, K K; Madsen, U; Krogsgaard-Larsen, P; Brehm, L.

    In: Journal of Medicinal Chemistry, Vol. 41, No. 6, 12.03.1998, p. 930-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands. / Johansen, T N; Frydenvang, Karla Andrea; Ebert, B; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 37, No. 20, 1994, p. 3252-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. Published
  15. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. / Johansen, Tommy N; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 15, No. 2, 2003, p. 167-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid. / Karla, Rolf; Ebert, Bjarke; Thorkildsen, Christian; Herdeis, Claus; Johansen, Tommy Nørskov; Nielsen, Birgitte; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 42, 1999, p. 2053-2059.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists : Ibotenic acid as a key lead structure. / Krogsgaard-Larsen, P.; Ebert, B.; Lund, Trine Meldgaard; Bräuner-Osborne, H.; Sloøk, F. A.; Johansen, T. N.; Brehm, L.; Madsen, U.

    In: European Journal of Medicinal Chemistry, Vol. 31, No. 7-8, 10.09.1996, p. 515-537.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Palladium-catalyzed monoamination of dihalogenated benzenes. / Larsen, Simon Birksø; Bang-Andersen, Benny; Johansen, Tommy Nørskov; Jørgensen, Morten.

    In: Tetrahedron, Vol. 64, No. 13, 2008, p. 2938-2950.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. / Lolli, Marco L; Giordano, Cecilia; Pickering, Darryl S; Rolando, Barbara; Hansen, Kasper B; Foti, Antonio; Contreras-Sanz, Alberto; Amir, Ahmad; Fruttero, Roberta; Gasco, Alberto; Nielsen, Birgitte; Johansen, Tommy N.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 10, 2010, p. 4110-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds. / Lolli, Marco L.; Hansen, Suzanne L. ; Rolando, Barbara ; Nielsen, Birgitte; Wellendorph, Petrine; Madsen, Karsten ; Larsen, Orla Miller ; Kristiansen, Uffe; Fruttero, Roberta ; Gasco, Alberto ; Johansen, Tommy Nørskov.

    In: J. Med. Chem., Vol. 49, 2006, p. 4442-4446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies. / Madsen, Kim G; Skonberg, Christian; Jurva, Ulrik; Cornett, Claus; Hansen, Steen H; Johansen, Tommy N; Olsen, Jørgen.

    In: Chemical Research in Toxicology, Vol. 21, No. 5, 2008, p. 1107-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. / Madsen, U; Bräuner-Osborne, H; Frydenvang, Karla Andrea; Hvene, L; Johansen, T N; Nielsen, B; Sánchez, C; Stensbøl, T B; Bischoff, F; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001, p. 1051-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders. / Madsen, Ulf; Greenwood, J; Johansen, Tommy Nørskov; Krogsgaard-Larsen, Povl; Liljefors, Tommy; Nielsen, Mogens ; Frølund, Bente.

    Drug Discovery Handbook. Wiley, 2005. p. 797–907.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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