Tommy Nørskov Johansen

Tommy Nørskov Johansen

Associate Professor / Head of Studies


  1. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. / Ahmadian, H; Nielsen, B; Bräuner-Osborne, Hans; Johansen, T N; Stensbøl, T B; Sløk, F A; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 40, No. 22, 24.10.1997, p. 3700-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. / Szymanska, Ewa; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy N.

    In: Bioorganic & Medicinal Chemistry, Vol. 17, No. 17, 2009, p. 6390-401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing. / Zimmermann, D.; Janin, Y.L.; Brehm, L.; Bräuner-Osborne, Hans; Ebert, B.; Johansen, T.N.; Madsen, U.; Krogsgaard-Larsen, P.

    In: European Journal of Medicinal Chemistry, Vol. 34, No. 11, 01.11.1999, p. 967-976.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. / Lolli, Marco L; Giordano, Cecilia; Pickering, Darryl S; Rolando, Barbara; Hansen, Kasper B; Foti, Antonio; Contreras-Sanz, Alberto; Amir, Ahmad; Fruttero, Roberta; Gasco, Alberto; Nielsen, Birgitte; Johansen, Tommy N.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 10, 2010, p. 4110-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2. / Bräuner-Osborne, Hans; Hermit, M B; Nielsen, B; Krogsgaard-Larsen, P; Johansen, T N.

    In: European Journal of Pharmacology, Vol. 406, No. 1, 06.10.2000, p. 41-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors. / Vogensen, SB; Greenwood, JR; Varming, Annemarie R.; Brehm, L; Pickering, DS; Nielsen, Birgitte; Liljefors, T; Clausen, Rasmus Prætorius; Johansen, Tommy Nørskov; Krogsgaard-Larsen, P.

    In: Organic & Biomolecular Chemistry, Vol. 2, No. 2, 2004, p. 206-213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects. / Skjærbæk, Niels; Brehm, Lotte; Johansen, Tommy Nørskov; Hansen, Lene M.; Nielsen, Birgitte; Ebert, Bjarke; Søby, Karina; Stensbøl, Tine B.; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 6, No. 1, 1998, p. 119-131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands. / Szymańska, Ewa; Chałupnik, Paulina; Johansen, Tommy Nørskov; Nielsen, Birgitte; Cuñado Moral, Ana Maria; Pickering, Darryl S; Kieć-Kononowicz, Katarzyna.

    In: Chemical Biology & Drug Design, Vol. 90, 01.12.2017, p. 1271-1281.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies. / Madsen, Kim G; Skonberg, Christian; Jurva, Ulrik; Cornett, Claus; Hansen, Steen H; Johansen, Tommy N; Olsen, Jørgen.

    In: Chemical Research in Toxicology, Vol. 21, No. 5, 2008, p. 1107-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. / Vogensen, SB; Clausen, Rasmus Prætorius; Greenwood, JR; Johansen, Tommy Nørskov; Pickering, DS; Nielsen, Birgitte; Ebert, Barke; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 9, 05.05.2005, p. 3438-3442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists : Ibotenic acid as a key lead structure. / Krogsgaard-Larsen, P.; Ebert, B.; Lund, Trine Meldgaard; Bräuner-Osborne, H.; Sloøk, F. A.; Johansen, T. N.; Brehm, L.; Madsen, U.

    In: European Journal of Medicinal Chemistry, Vol. 31, No. 7-8, 10.09.1996, p. 515-537.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published
  16. Published

    Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. / Szymańska, Ewa; Chałupnik, Paulina; Szczepańska, Katarzyna; Moral, Ana Maria Cuñado; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy Nørskov; Kieć-Kononowicz, Kieć-Kononowicz.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 22, 2016, p. 5568-5572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. / Johansen, T N; Ebert, B; Bräuner-Osborne, Hans; Didriksen, M; Christensen, I T; Søby, K K; Madsen, U; Krogsgaard-Larsen, P; Brehm, L.

    In: Journal of Medicinal Chemistry, Vol. 41, No. 6, 12.03.1998, p. 930-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. / Jensen, Anders A.; Christesen, Thomas; Bølcho, Ulrik; Greenwood, Jeremy R; Postorino, Giovanna; Vogensen, Stine B; Johansen, Tommy N; Egebjerg, Jan; Bräuner-Osborne, Hans; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 17, 2007, p. 4177-4185.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders. / Madsen, Ulf; Greenwood, J; Johansen, Tommy Nørskov; Krogsgaard-Larsen, Povl; Liljefors, Tommy; Nielsen, Mogens ; Frølund, Bente.

    Drug Discovery Handbook. Wiley, 2005. p. 797–907.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  21. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. / Falch, Erik; Brehm, Lotte; Mikkelsen, Ivan; Johansen, Tommy Nørskov; Skjærbæk, Niels; Nielsen, Birgitte; Stensbøl, Tine B.; Ebert, Bjarke; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 41, 1998, p. 2513-2523.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds. / Lolli, Marco L.; Hansen, Suzanne L. ; Rolando, Barbara ; Nielsen, Birgitte; Wellendorph, Petrine; Madsen, Karsten ; Larsen, Orla Miller ; Kristiansen, Uffe; Fruttero, Roberta ; Gasco, Alberto ; Johansen, Tommy Nørskov.

    In: J. Med. Chem., Vol. 49, 2006, p. 4442-4446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors. / Bräuner-Osborne, Hans; Nielsen, B; Stensbøl, T B; Johansen, T N; Skjaerbaek, N; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 335, No. 2-3, 24.09.1997, p. R1-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

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