Tommy Nørskov Johansen

Tommy Nørskov Johansen

Associate Professor / Head of Studies


  1. Published

    The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. / Jensen, Anders A.; Mosbacher, Johannes; Elg, Susanne; Lingenhoehl, Kurt; Lohmann, Tania; Johansen, Tommy N; Abrahamsen, Bjarke; Mattsson, Jan; Lehmann, Anders; Bettler, Bernhard; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 61, No. 6, 2002, p. 1377-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands. / Johansen, T N; Frydenvang, Karla Andrea; Ebert, B; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 37, No. 20, 1994, p. 3252-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands. / Bunch, L; Johansen, T H; Bräuner-Osborne, Hans; Stensbøl, T B; Johansen, T N; Krogsgaard-Larsen, P; Madsen, U.

    In: Bioorganic & Medicinal Chemistry, Vol. 9, No. 4, 04.2001, p. 875-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. / Madsen, U; Bräuner-Osborne, H; Frydenvang, Karla Andrea; Hvene, L; Johansen, T N; Nielsen, B; Sánchez, C; Stensbøl, T B; Bischoff, F; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001, p. 1051-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid. / Karla, Rolf; Ebert, Bjarke; Thorkildsen, Christian; Herdeis, Claus; Johansen, Tommy Nørskov; Nielsen, Birgitte; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 42, 1999, p. 2053-2059.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors. / Sløk, Frank A; Bräuner-Osborne, Hans; Stensbøl, Tine B; Johansen, Tommy Nørskov; Ebert, Bjarke; Mortensen, Martin; Nielsen, Birgitte; Madsen, Ulf; Brehm, Lotte; Falch, Erik; Krogsgaard-Larsen, Povl.

    Medicinal Chemistry into the Millenium. ed. / Malcolm M Campbell; Ian S Blagbrough. UK : Royal Society of Chemistry, 2001. p. 52-64.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. / Johansen, Tommy N; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 15, No. 2, 2003, p. 167-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist. / Stensbøl, T B; Jensen, H S; Nielsen, B; Johansen, T N; Egebjerg, J; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 411, No. 3, 2001, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Selektive lægemiddelstoffer designet ud fra krystalstrukturer. / Szymanska, Ewa Monika; Johansen, Tommy Nørskov.

    In: Lægemiddelforskning, 2007, p. 34-35.

    Research output: Contribution to journalJournal articleCommunication

  14. Published

    Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist. / Vogensen, S B; Jensen, H S; Stensbøl, T B; Frydenvang, Karla Andrea; Bang-Andersen, B; Johansen, T N; Egebjerg, J; Krogsgaard-Larsen, P.

    In: Chirality, Vol. 12, No. 10, 2000, p. 705-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published
  16. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  17. Published

    Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. / Szymańska, Ewa; Nielsen, Birgitte; Johansen, Tommy Nørskov; Cuñado Moral, Anna Maria; Pickering, Darryl S; Szczepańska, Katarzyna; Mickowska, Anna; Kieć-Kononowicz, Katarzyna.

    In: European Journal of Medicinal Chemistry, Vol. 138, 2017, p. 874-883.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Palladium-catalyzed monoamination of dihalogenated benzenes. / Larsen, Simon Birksø; Bang-Andersen, Benny; Johansen, Tommy Nørskov; Jørgensen, Morten.

    In: Tetrahedron, Vol. 64, No. 13, 2008, p. 2938-2950.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors. / Bräuner-Osborne, Hans; Nielsen, B; Stensbøl, T B; Johansen, T N; Skjaerbaek, N; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 335, No. 2-3, 24.09.1997, p. R1-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds. / Lolli, Marco L.; Hansen, Suzanne L. ; Rolando, Barbara ; Nielsen, Birgitte; Wellendorph, Petrine; Madsen, Karsten ; Larsen, Orla Miller ; Kristiansen, Uffe; Fruttero, Roberta ; Gasco, Alberto ; Johansen, Tommy Nørskov.

    In: J. Med. Chem., Vol. 49, 2006, p. 4442-4446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. / Falch, Erik; Brehm, Lotte; Mikkelsen, Ivan; Johansen, Tommy Nørskov; Skjærbæk, Niels; Nielsen, Birgitte; Stensbøl, Tine B.; Ebert, Bjarke; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 41, 1998, p. 2513-2523.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders. / Madsen, Ulf; Greenwood, J; Johansen, Tommy Nørskov; Krogsgaard-Larsen, Povl; Liljefors, Tommy; Nielsen, Mogens ; Frølund, Bente.

    Drug Discovery Handbook. Wiley, 2005. p. 797–907.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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