1,2,3-triazolyl amino acids as AMPA receptor ligands

Research output: Contribution to journalJournal articleResearchpeer-review

Nathan J. Stanley, Daniel Sejer Pedersen, Birgitte Nielsen, Trine Kvist, Jesper M Mathiesen, Hans Bräuner-Osborne, Dennis K Taylor, Andrew D Abell

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume20
Issue number24
Pages (from-to)7512-7515
ISSN0960-894X
DOIs
Publication statusPublished - 15 Dec 2010

Bibliographical note

Keywords: synthesis; glutamate receptor; triazole

ID: 32132476