2-(2,3-Dihydro-1H-indol-3-yl)ethanol: synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis
Research output: Contribution to journal › Journal article › Research › peer-review
Karla Andrea Frydenvang, Michael Bech Sommer, Dieter Heckmann, Ole Nielsen, Benny Bang-Andersen
The first direct resolution of racemic 2-(2,3-dihydro-lH-indol-3-yl)ethanol-prepared by catalytic hydrogenation of 2-(lH-indol-3-yl)ethanol-has been accomplished by chiral simulated moving bed (SMB) chromatography. The single enantiomers were isolated as their dihydrogen phosphate salts. Single-crystal X-ray analyses were successful, revealing that the (+)-enantiomer of 2-(2,3-dihydro-lH-indol-3-yl)ethanol has the (S) configuration. Chirality 16:126-130, 2004.
|Number of pages||5|
|Publication status||Published - 2004|
- Chromatography, High Pressure Liquid, Crystallography, X-Ray, Ethanol, Hydrogen, Indoles, Ligands, Models, Molecular, Molecular Conformation, Molecular Structure, Phosphates, Receptors, Dopamine D2, Receptors, Dopamine D4, Stereoisomerism