2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Research output: Contribution to journalJournal articleResearchpeer-review

Katrine B Hansen, Mette M Rosenkilde, Filip K Knop, Niels Wellner, Thi A Diep, Jens F Rehfeld, Ulrik B Andersen, Jens J Holst, Harald S. Hansen

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number9
Pages (from-to)E1409-17
ISSN0021-972X
DOIs
Publication statusPublished - 2011

    Research areas

  • Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled
  • The Faculty of Pharmaceutical Sciences

ID: 36082144