A heteromeric snake toxin and the molecular details of pain perception

Research output: Contribution to journalJournal articleResearchpeer-review

Gaining on pain: Two snake protein toxins combine to form a heteromeric complex, MitTx, which activates acid-sensing ion channels (ASICs) and elicits pain. MitTx is used to explore the roles of specific ASIC subtypes in pain pathways. These insights may provide new pharmacological tools ultimately leading to new treatments for pain.
Original languageEnglish
JournalAngewandte Chemie International Edition
Issue number17
Pages (from-to)4009-4011
Publication statusPublished - 23 Apr 2012

Bibliographical note

Keywords: ion channels; pain; natural products; snake toxins

ID: 37797330