A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

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A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina. / Toft-Kehler, A K; Skytt, D M; Kolko, Miriam.

In: Molecular Neurobiology, Vol. 55, No. 6, 06.2018, p. 5353–5361.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Toft-Kehler, AK, Skytt, DM & Kolko, M 2018, 'A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina', Molecular Neurobiology, vol. 55, no. 6, pp. 5353–5361. https://doi.org/10.1007/s12035-017-0760-7

APA

Toft-Kehler, A. K., Skytt, D. M., & Kolko, M. (2018). A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina. Molecular Neurobiology, 55(6), 5353–5361. https://doi.org/10.1007/s12035-017-0760-7

Vancouver

Toft-Kehler AK, Skytt DM, Kolko M. A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina. Molecular Neurobiology. 2018 Jun;55(6):5353–5361. https://doi.org/10.1007/s12035-017-0760-7

Author

Toft-Kehler, A K ; Skytt, D M ; Kolko, Miriam. / A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina. In: Molecular Neurobiology. 2018 ; Vol. 55, No. 6. pp. 5353–5361.

Bibtex

@article{228c32871687467d91dcad3a780c0a2b,
title = "A Perspective on the M{\"u}ller Cell-Neuron Metabolic Partnership in the Inner Retina",
abstract = "The M{\"u}ller cells represent the predominant macroglial cell in the retina. In recent decades, M{\"u}ller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, M{\"u}ller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by M{\"u}ller cells. The present review provides a perspective on the symbiotic relationship between M{\"u}ller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within M{\"u}ller cells in relation to retinal neuron survival.",
keywords = "Journal Article, Review",
author = "Toft-Kehler, {A K} and Skytt, {D M} and Miriam Kolko",
year = "2018",
month = "6",
doi = "10.1007/s12035-017-0760-7",
language = "English",
volume = "55",
pages = "5353–5361",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

AU - Toft-Kehler, A K

AU - Skytt, D M

AU - Kolko, Miriam

PY - 2018/6

Y1 - 2018/6

N2 - The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

AB - The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

KW - Journal Article

KW - Review

U2 - 10.1007/s12035-017-0760-7

DO - 10.1007/s12035-017-0760-7

M3 - Review

C2 - 28929338

VL - 55

SP - 5353

EP - 5361

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 6

ER -

ID: 186876739