A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

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Juan J Rubal, F Javier Moreno-Dorado, Francisco M Guerra, Zacarías D Jorge, María del Carmen Galán, Ginés M Salido, Søren Brøgger Christensen, Helmer Søhoel, Guillermo M Massanet

A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.
Original languageEnglish
JournalPlanta Medica
Issue number3
Pages (from-to)284-290
Publication statusPublished - 2010

Bibliographical note

Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors

ID: 14119578