A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008-2011)

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Gaby van Galen Verwilghen, A. Leblond, P. Tritz, Ludovic Martinelle, Stéphane Pronost, C. Saegerman

Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but early
recognition and knowledge of risk factors are essential for prevention and control. The objectives for this
study are to (1) describe EHM in France, (2) improve clinical recognition, (3) identify risk factors. Through
epidemiosurveillance of acute neurological cases (all considered to be potentially infectious cases) in
France (2008–2011), 26 EHM cases were identified and 29 EHM negative control cases. EHM cases were
described and compared to controls with univariate, multivariate and classification and regression tree
analysis. EHM cases had a 46% fatality rate and were frequently isolated cases. Most showed ataxia,
paresis and a cauda equina syndrome, yet presence of other neurological signs was variable. Statistical
analysis identified the following variables to be significantly associated to EHM compared to controls:
introduction of a new horse to the herd, cauda equina syndrome, larger herd size, saddle horses and
month of occurrence. The presence of many isolated cases, and less typical and variable clinical
presentations emphasize the difficulty in diagnosing EHM. Nevertheless, history and clinical examination
of acute neurological cases can be valuable in recognizing EHM early as well in order to select those cases
that need further laboratory testing and infection control measures. Moreover, with a different study
format and geographic location, risk factors were found to be similar to previous studies, therefore
strengthening their significance to the spread of EHM.
Original languageEnglish
JournalVeterinary Microbiology
Volume179
Issue number3-4
Pages (from-to)304-309
Number of pages6
ISSN0378-1135
DOIs
Publication statusPublished - 8 Jul 2015
Externally publishedYes

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