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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

Research output: Contribution to journalJournal articleResearchpeer-review

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A strategic approach to [6,6]-bicyclic lactones : application towards the CD fragment of DHβE. / Jepsen, Tue Heesgaard; Glibstrup, Emil; Crestey, Francois Louis Jean; Jensen, Anders A.; Kristensen, Jesper Langgaard.

In: Beilstein Journal of Organic Chemistry, Vol. 13, 2017, p. 988-994.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jepsen, TH, Glibstrup, E, Crestey, FLJ, Jensen, AA & Kristensen, JL 2017, 'A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE' Beilstein Journal of Organic Chemistry, vol. 13, pp. 988-994. https://doi.org/10.3762/bjoc.13.98

APA

Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, A. A., & Kristensen, J. L. (2017). A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE. Beilstein Journal of Organic Chemistry, 13, 988-994. https://doi.org/10.3762/bjoc.13.98

Vancouver

Jepsen TH, Glibstrup E, Crestey FLJ, Jensen AA, Kristensen JL. A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE. Beilstein Journal of Organic Chemistry. 2017;13:988-994. https://doi.org/10.3762/bjoc.13.98

Author

Jepsen, Tue Heesgaard ; Glibstrup, Emil ; Crestey, Francois Louis Jean ; Jensen, Anders A. ; Kristensen, Jesper Langgaard. / A strategic approach to [6,6]-bicyclic lactones : application towards the CD fragment of DHβE. In: Beilstein Journal of Organic Chemistry. 2017 ; Vol. 13. pp. 988-994.

Bibtex

@article{3a9431dff8e240229f21df1c8e9427e7,
title = "A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE",
abstract = "We report an effective synthetic protocol to access [6,6]-bicyclic lactone moieties through a regio- and stereoselective intramolecular Mizoroki–Heck cross-coupling reaction followed by a 6π-electrocyclization. This method enabled the first synthesis of the elusive CD fragment of the Erythrina alkaloid DHβE. Preliminary pharmacological evaluations support the notion that the key pharmacophores of DHβE are located in the A and B rings.",
author = "Jepsen, {Tue Heesgaard} and Emil Glibstrup and Crestey, {Francois Louis Jean} and Jensen, {Anders A.} and Kristensen, {Jesper Langgaard}",
year = "2017",
doi = "10.3762/bjoc.13.98",
language = "English",
volume = "13",
pages = "988--994",
journal = "Beilstein Journal of Organic Chemistry",
issn = "2195-951X",
publisher = "Beilstein - Institut zur Foerderung der Chemischen Wissenschaften",

}

RIS

TY - JOUR

T1 - A strategic approach to [6,6]-bicyclic lactones

T2 - application towards the CD fragment of DHβE

AU - Jepsen, Tue Heesgaard

AU - Glibstrup, Emil

AU - Crestey, Francois Louis Jean

AU - Jensen, Anders A.

AU - Kristensen, Jesper Langgaard

PY - 2017

Y1 - 2017

N2 - We report an effective synthetic protocol to access [6,6]-bicyclic lactone moieties through a regio- and stereoselective intramolecular Mizoroki–Heck cross-coupling reaction followed by a 6π-electrocyclization. This method enabled the first synthesis of the elusive CD fragment of the Erythrina alkaloid DHβE. Preliminary pharmacological evaluations support the notion that the key pharmacophores of DHβE are located in the A and B rings.

AB - We report an effective synthetic protocol to access [6,6]-bicyclic lactone moieties through a regio- and stereoselective intramolecular Mizoroki–Heck cross-coupling reaction followed by a 6π-electrocyclization. This method enabled the first synthesis of the elusive CD fragment of the Erythrina alkaloid DHβE. Preliminary pharmacological evaluations support the notion that the key pharmacophores of DHβE are located in the A and B rings.

U2 - 10.3762/bjoc.13.98

DO - 10.3762/bjoc.13.98

M3 - Journal article

VL - 13

SP - 988

EP - 994

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

SN - 2195-951X

ER -

ID: 178457431