Acoustic monitoring of a fluidized bed coating process

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Acoustic monitoring of a fluidized bed coating process. / Naelapaa, Kaisa; Veski, Peep; Pedersen, Joan G.; Anov, Dan; Jørgensen, Pia; Kristensen, Henning Gjelstrup; Bertelsen, Poul.

In: Internation Journal of Pharmaceutics, Vol. 332, No. 1-2, 2007, p. 90-97.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Naelapaa, K, Veski, P, Pedersen, JG, Anov, D, Jørgensen, P, Kristensen, HG & Bertelsen, P 2007, 'Acoustic monitoring of a fluidized bed coating process', Internation Journal of Pharmaceutics, vol. 332, no. 1-2, pp. 90-97. https://doi.org/10.1016/j.ijpharm.2006.09.036

APA

Naelapaa, K., Veski, P., Pedersen, J. G., Anov, D., Jørgensen, P., Kristensen, H. G., & Bertelsen, P. (2007). Acoustic monitoring of a fluidized bed coating process. Internation Journal of Pharmaceutics, 332(1-2), 90-97. https://doi.org/10.1016/j.ijpharm.2006.09.036

Vancouver

Naelapaa K, Veski P, Pedersen JG, Anov D, Jørgensen P, Kristensen HG et al. Acoustic monitoring of a fluidized bed coating process. Internation Journal of Pharmaceutics. 2007;332(1-2):90-97. https://doi.org/10.1016/j.ijpharm.2006.09.036

Author

Naelapaa, Kaisa ; Veski, Peep ; Pedersen, Joan G. ; Anov, Dan ; Jørgensen, Pia ; Kristensen, Henning Gjelstrup ; Bertelsen, Poul. / Acoustic monitoring of a fluidized bed coating process. In: Internation Journal of Pharmaceutics. 2007 ; Vol. 332, No. 1-2. pp. 90-97.

Bibtex

@article{e9b33470a6b511ddb5e9000ea68e967b,
title = "Acoustic monitoring of a fluidized bed coating process",
abstract = "  The aim of the study was to investigate the potential of acoustic monitoring of a production scale fluidized bed coating process. The correlation between sensor signals and the estimated amount of film applied and percentage release, respectively, were investigated in coating potassium chloride (KCl) crystals with ethylcellulose (EC). Vibrations were measured with two different types of accelerometers. Different positions for placing the accelerometers and two different product containers were included in the study. Top spray coating of KCl was chosen as a ‘worst case' scenario from a coating point perspective. The acoustic monitoring has the potential of summarising the commonly used means to monitor the coating process. The best partial least squares (PLS) regressions, obtained by the high frequency accelerometer, showed for the release a correlation coefficient of 0.92 and a root mean square error of prediction (RMSEP) of 5.84{\%} (31-82.8{\%}), and for the estimated amount of film applied a correlation coefficient of 0.95 and RMSEP of 0.52{\%} (0.6-6{\%}). The results of the preliminary investigation are considered promising. There is however a need for further investigations on sampling procedures and product characterisation before a final conclusion on the applicability of acoustic monitoring can be made.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Kaisa Naelapaa and Peep Veski and Pedersen, {Joan G.} and Dan Anov and Pia J{\o}rgensen and Kristensen, {Henning Gjelstrup} and Poul Bertelsen",
year = "2007",
doi = "10.1016/j.ijpharm.2006.09.036",
language = "English",
volume = "332",
pages = "90--97",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Acoustic monitoring of a fluidized bed coating process

AU - Naelapaa, Kaisa

AU - Veski, Peep

AU - Pedersen, Joan G.

AU - Anov, Dan

AU - Jørgensen, Pia

AU - Kristensen, Henning Gjelstrup

AU - Bertelsen, Poul

PY - 2007

Y1 - 2007

N2 -   The aim of the study was to investigate the potential of acoustic monitoring of a production scale fluidized bed coating process. The correlation between sensor signals and the estimated amount of film applied and percentage release, respectively, were investigated in coating potassium chloride (KCl) crystals with ethylcellulose (EC). Vibrations were measured with two different types of accelerometers. Different positions for placing the accelerometers and two different product containers were included in the study. Top spray coating of KCl was chosen as a ‘worst case' scenario from a coating point perspective. The acoustic monitoring has the potential of summarising the commonly used means to monitor the coating process. The best partial least squares (PLS) regressions, obtained by the high frequency accelerometer, showed for the release a correlation coefficient of 0.92 and a root mean square error of prediction (RMSEP) of 5.84% (31-82.8%), and for the estimated amount of film applied a correlation coefficient of 0.95 and RMSEP of 0.52% (0.6-6%). The results of the preliminary investigation are considered promising. There is however a need for further investigations on sampling procedures and product characterisation before a final conclusion on the applicability of acoustic monitoring can be made.

AB -   The aim of the study was to investigate the potential of acoustic monitoring of a production scale fluidized bed coating process. The correlation between sensor signals and the estimated amount of film applied and percentage release, respectively, were investigated in coating potassium chloride (KCl) crystals with ethylcellulose (EC). Vibrations were measured with two different types of accelerometers. Different positions for placing the accelerometers and two different product containers were included in the study. Top spray coating of KCl was chosen as a ‘worst case' scenario from a coating point perspective. The acoustic monitoring has the potential of summarising the commonly used means to monitor the coating process. The best partial least squares (PLS) regressions, obtained by the high frequency accelerometer, showed for the release a correlation coefficient of 0.92 and a root mean square error of prediction (RMSEP) of 5.84% (31-82.8%), and for the estimated amount of film applied a correlation coefficient of 0.95 and RMSEP of 0.52% (0.6-6%). The results of the preliminary investigation are considered promising. There is however a need for further investigations on sampling procedures and product characterisation before a final conclusion on the applicability of acoustic monitoring can be made.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.ijpharm.2006.09.036

DO - 10.1016/j.ijpharm.2006.09.036

M3 - Journal article

VL - 332

SP - 90

EP - 97

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 8299256