Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

Research output: Contribution to journalJournal articleResearchpeer-review

Christian A Olsen, Caspar Christensen, Birgitte Nielsen, Mohamed M Farah, Farah M Mohamed, Matthias Witt, Rasmus P Clausen, Jesper L Kristensen, Henrik Franzyk, Jerzy W Jaroszewski

[Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.
Original languageEnglish
JournalOrganic Letters
Volume8
Issue number15
Pages (from-to)3371-4
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2006

    Research areas

  • Amino Alcohols, Aziridines, Carboxylic Acids, Heterocyclic Compounds, Molecular Structure, Stereoisomerism

ID: 42352810