Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids
Research output: Contribution to journal › Journal article › Research › peer-review
[Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.
|Number of pages||4|
|Publication status||Published - 2006|
- Amino Alcohols, Aziridines, Carboxylic Acids, Heterocyclic Compounds, Molecular Structure, Stereoisomerism