Analysing the distribution of synaptic vesicles using a spatial point process model

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Mahdieh Khanmohammadi, Rasmus Waagepetersen, Nicoletta Nava, Jens Nyengaard, Jon Sporring

Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.
We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.
Original languageEnglish
Title of host publicationProceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
Number of pages6
PublisherAssociation for Computing Machinery
Publication date2014
Pages73-78
ISBN (Electronic)978-1-4503-2894-4
DOIs
Publication statusPublished - 2014
Event5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics - Newport Beach Marriott Hotel & Spa, Newport Beach, United States
Duration: 20 Sep 201423 Sep 2014
Conference number: 5

Conference

Conference5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
Nummer5
LocationNewport Beach Marriott Hotel & Spa
LandUnited States
ByNewport Beach
Periode20/09/201423/09/2014

ID: 159741105