Antiprotozoal compounds from Asparagus africanus

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Antiprotozoal compounds from Asparagus africanus. / Oketch-Rabah, H A; Dossaji, S F; Christensen, S B; Frydenvang, K; Lemmich, E; Cornett, C; Olsen, C E; Chen, M; Kharazmi, A; Theander, T.

In: Journal of Natural Products, Vol. 60, No. 10, 1997, p. 1017-22.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Oketch-Rabah, HA, Dossaji, SF, Christensen, SB, Frydenvang, K, Lemmich, E, Cornett, C, Olsen, CE, Chen, M, Kharazmi, A & Theander, T 1997, 'Antiprotozoal compounds from Asparagus africanus', Journal of Natural Products, vol. 60, no. 10, pp. 1017-22. https://doi.org/10.1021/np970217f

APA

Oketch-Rabah, H. A., Dossaji, S. F., Christensen, S. B., Frydenvang, K., Lemmich, E., Cornett, C., ... Theander, T. (1997). Antiprotozoal compounds from Asparagus africanus. Journal of Natural Products, 60(10), 1017-22. https://doi.org/10.1021/np970217f

Vancouver

Oketch-Rabah HA, Dossaji SF, Christensen SB, Frydenvang K, Lemmich E, Cornett C et al. Antiprotozoal compounds from Asparagus africanus. Journal of Natural Products. 1997;60(10):1017-22. https://doi.org/10.1021/np970217f

Author

Oketch-Rabah, H A ; Dossaji, S F ; Christensen, S B ; Frydenvang, K ; Lemmich, E ; Cornett, C ; Olsen, C E ; Chen, M ; Kharazmi, A ; Theander, T. / Antiprotozoal compounds from Asparagus africanus. In: Journal of Natural Products. 1997 ; Vol. 60, No. 10. pp. 1017-22.

Bibtex

@article{05fa2590a0d911dd86a6000ea68e967b,
title = "Antiprotozoal compounds from Asparagus africanus",
abstract = "Two antiprotozoal compounds have been isolated from the roots of Asparagus africanus Lam. (Liliaceae), a new sapogenin, 2 beta, 12 alpha-dihydroxy-(25R)-spirosta-4,7-dien-3-one (1), which was named muzanzagenin, and the lignan (+)-nyasol (2), (Z)-(+)-4,4'-(3-ethenyl-1-propene-1,3-diyl)-bisphenol. The structure of the sapogenin was elucidated by MS and by 1D and 2D NMR methods and established by a single crystal X-ray analysis. (+)-Nyasol potently inhibits the growth of Leishmania major promastigotes, the IC50 being 12 microM, and moderately inhibits Plasmodium falciparum schizonts with the IC50 49 microM. These concentrations only moderately affect the proliferation of human lymphocytes. Muzanzagenin showed a moderate in vitro activity in all three tests, the IC50 against leishmania promastigotes was 70 microM, and against four different malaria schizont strains the IC50 values were 16, 163, 23, and 16 microM, respectively.",
author = "Oketch-Rabah, {H A} and Dossaji, {S F} and Christensen, {S B} and K Frydenvang and E Lemmich and C Cornett and Olsen, {C E} and M Chen and A Kharazmi and T Theander",
note = "Keywords: Animals; Antiprotozoal Agents; Cell Division; Humans; Leishmania major; Liliaceae; Lymphocytes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenols; Plasmodium falciparum; Sapogenins",
year = "1997",
doi = "10.1021/np970217f",
language = "English",
volume = "60",
pages = "1017--22",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "10",

}

RIS

TY - JOUR

T1 - Antiprotozoal compounds from Asparagus africanus

AU - Oketch-Rabah, H A

AU - Dossaji, S F

AU - Christensen, S B

AU - Frydenvang, K

AU - Lemmich, E

AU - Cornett, C

AU - Olsen, C E

AU - Chen, M

AU - Kharazmi, A

AU - Theander, T

N1 - Keywords: Animals; Antiprotozoal Agents; Cell Division; Humans; Leishmania major; Liliaceae; Lymphocytes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenols; Plasmodium falciparum; Sapogenins

PY - 1997

Y1 - 1997

N2 - Two antiprotozoal compounds have been isolated from the roots of Asparagus africanus Lam. (Liliaceae), a new sapogenin, 2 beta, 12 alpha-dihydroxy-(25R)-spirosta-4,7-dien-3-one (1), which was named muzanzagenin, and the lignan (+)-nyasol (2), (Z)-(+)-4,4'-(3-ethenyl-1-propene-1,3-diyl)-bisphenol. The structure of the sapogenin was elucidated by MS and by 1D and 2D NMR methods and established by a single crystal X-ray analysis. (+)-Nyasol potently inhibits the growth of Leishmania major promastigotes, the IC50 being 12 microM, and moderately inhibits Plasmodium falciparum schizonts with the IC50 49 microM. These concentrations only moderately affect the proliferation of human lymphocytes. Muzanzagenin showed a moderate in vitro activity in all three tests, the IC50 against leishmania promastigotes was 70 microM, and against four different malaria schizont strains the IC50 values were 16, 163, 23, and 16 microM, respectively.

AB - Two antiprotozoal compounds have been isolated from the roots of Asparagus africanus Lam. (Liliaceae), a new sapogenin, 2 beta, 12 alpha-dihydroxy-(25R)-spirosta-4,7-dien-3-one (1), which was named muzanzagenin, and the lignan (+)-nyasol (2), (Z)-(+)-4,4'-(3-ethenyl-1-propene-1,3-diyl)-bisphenol. The structure of the sapogenin was elucidated by MS and by 1D and 2D NMR methods and established by a single crystal X-ray analysis. (+)-Nyasol potently inhibits the growth of Leishmania major promastigotes, the IC50 being 12 microM, and moderately inhibits Plasmodium falciparum schizonts with the IC50 49 microM. These concentrations only moderately affect the proliferation of human lymphocytes. Muzanzagenin showed a moderate in vitro activity in all three tests, the IC50 against leishmania promastigotes was 70 microM, and against four different malaria schizont strains the IC50 values were 16, 163, 23, and 16 microM, respectively.

U2 - 10.1021/np970217f

DO - 10.1021/np970217f

M3 - Journal article

VL - 60

SP - 1017

EP - 1022

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -

ID: 6766166