Astrocytic GABA transporter activity modulates excitatory neurotransmission

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Astrocytic GABA transporter activity modulates excitatory neurotransmission. / Boddum, Kim; Jensen, Thomas P.; Magloire, Vincent; Kristiansen, Uffe; Rusakov, Dmitri A; Pavlov, Ivan; Walker, Matthew C.

In: Nature Communications, Vol. 7, 13572, 25.11.2016.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Boddum, K, Jensen, TP, Magloire, V, Kristiansen, U, Rusakov, DA, Pavlov, I & Walker, MC 2016, 'Astrocytic GABA transporter activity modulates excitatory neurotransmission', Nature Communications, vol. 7, 13572. https://doi.org/10.1038/ncomms13572

APA

Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, U., Rusakov, D. A., Pavlov, I., & Walker, M. C. (2016). Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Communications, 7, [13572]. https://doi.org/10.1038/ncomms13572

Vancouver

Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I et al. Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Communications. 2016 Nov 25;7. 13572. https://doi.org/10.1038/ncomms13572

Author

Boddum, Kim ; Jensen, Thomas P. ; Magloire, Vincent ; Kristiansen, Uffe ; Rusakov, Dmitri A ; Pavlov, Ivan ; Walker, Matthew C. / Astrocytic GABA transporter activity modulates excitatory neurotransmission. In: Nature Communications. 2016 ; Vol. 7.

Bibtex

@article{46d8065ced494b4da14d6ca61e7d9ae2,
title = "Astrocytic GABA transporter activity modulates excitatory neurotransmission",
abstract = "Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also express transporters that regulate the extracellular concentration of neurotransmitters. Here we report a previously unrecognized role for the astrocytic GABA transporter, GAT-3. GAT-3 activity results in a rise in astrocytic Na(+) concentrations and a consequent increase in astrocytic Ca(2+) through Na(+)/Ca(2+) exchange. This leads to the release of ATP/adenosine by astrocytes, which then diffusely inhibits neuronal glutamate release via activation of presynaptic adenosine receptors. Through this mechanism, increases in astrocytic GAT-3 activity due to GABA released from interneurons contribute to 'diffuse' heterosynaptic depression. This provides a mechanism for homeostatic regulation of excitatory transmission in the hippocampus.",
author = "Kim Boddum and Jensen, {Thomas P.} and Vincent Magloire and Uffe Kristiansen and Rusakov, {Dmitri A} and Ivan Pavlov and Walker, {Matthew C}",
year = "2016",
month = "11",
day = "25",
doi = "10.1038/ncomms13572",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Astrocytic GABA transporter activity modulates excitatory neurotransmission

AU - Boddum, Kim

AU - Jensen, Thomas P.

AU - Magloire, Vincent

AU - Kristiansen, Uffe

AU - Rusakov, Dmitri A

AU - Pavlov, Ivan

AU - Walker, Matthew C

PY - 2016/11/25

Y1 - 2016/11/25

N2 - Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also express transporters that regulate the extracellular concentration of neurotransmitters. Here we report a previously unrecognized role for the astrocytic GABA transporter, GAT-3. GAT-3 activity results in a rise in astrocytic Na(+) concentrations and a consequent increase in astrocytic Ca(2+) through Na(+)/Ca(2+) exchange. This leads to the release of ATP/adenosine by astrocytes, which then diffusely inhibits neuronal glutamate release via activation of presynaptic adenosine receptors. Through this mechanism, increases in astrocytic GAT-3 activity due to GABA released from interneurons contribute to 'diffuse' heterosynaptic depression. This provides a mechanism for homeostatic regulation of excitatory transmission in the hippocampus.

AB - Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also express transporters that regulate the extracellular concentration of neurotransmitters. Here we report a previously unrecognized role for the astrocytic GABA transporter, GAT-3. GAT-3 activity results in a rise in astrocytic Na(+) concentrations and a consequent increase in astrocytic Ca(2+) through Na(+)/Ca(2+) exchange. This leads to the release of ATP/adenosine by astrocytes, which then diffusely inhibits neuronal glutamate release via activation of presynaptic adenosine receptors. Through this mechanism, increases in astrocytic GAT-3 activity due to GABA released from interneurons contribute to 'diffuse' heterosynaptic depression. This provides a mechanism for homeostatic regulation of excitatory transmission in the hippocampus.

U2 - 10.1038/ncomms13572

DO - 10.1038/ncomms13572

M3 - Journal article

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 13572

ER -

ID: 169361154