Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains
Research output: Contribution to journal › Journal article › Research › peer-review
Line Hein-Kristensen, Kolja Michael Knapp, Henrik Franzyk, Lone Gram
Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subsequent killing is usually not tested. In this report, six a-peptide/ß-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates.
|Journal||B M C Microbiology|
|Publication status||Published - 22 Jun 2011|
- The Faculty of Pharmaceutical Sciences