Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

Research output: Contribution to journalJournal articleResearchpeer-review

  • Anna Katharina Jäger
  • Katrine Krydsfeldt
  • Hasse Bonde Rasmussen
Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.
Original languageEnglish
JournalPhytotherapy Research
Issue number11
Pages (from-to)1642-1644
Publication statusPublished - 2009

Bibliographical note

Keywords: apigenin; benzodiazepine site; GABA; Tanacetum parthenium

ID: 14148302