Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article

Research output: Contribution to journalJournal articleResearchpeer-review

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Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art : review article. / Harrison, Adrian Paul; Pierzynowski, S.G.

In: Journal of Physiology and Pharmacology, Vol. 59, No. Suppl. 1, 2008, p. 91-106.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Harrison, AP & Pierzynowski, SG 2008, 'Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article', Journal of Physiology and Pharmacology, vol. 59, no. Suppl. 1, pp. 91-106.

APA

Harrison, A. P., & Pierzynowski, S. G. (2008). Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article. Journal of Physiology and Pharmacology, 59(Suppl. 1), 91-106.

Vancouver

Harrison AP, Pierzynowski SG. Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article. Journal of Physiology and Pharmacology. 2008;59(Suppl. 1):91-106.

Author

Harrison, Adrian Paul ; Pierzynowski, S.G. / Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art : review article. In: Journal of Physiology and Pharmacology. 2008 ; Vol. 59, No. Suppl. 1. pp. 91-106.

Bibtex

@article{48988540a1c411ddb6ae000ea68e967b,
title = "Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article",
abstract = "The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.",
keywords = "Former LIFE faculty, 2-oxoglutarate, alpha keto glutarate (AKG), osteoporoses, melatonin, cholesterol, cancer, collagen, muscle, artery elasticity, mineral absorption",
author = "Harrison, {Adrian Paul} and S.G. Pierzynowski",
year = "2008",
language = "English",
volume = "59",
pages = "91--106",
journal = "Journal of Physiology and Pharmacology",
issn = "0867-5910",
publisher = "Polskie Towarzystwo Fizjologiczne",
number = "Suppl. 1",

}

RIS

TY - JOUR

T1 - Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art

T2 - review article

AU - Harrison, Adrian Paul

AU - Pierzynowski, S.G.

PY - 2008

Y1 - 2008

N2 - The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.

AB - The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.

KW - Former LIFE faculty

KW - 2-oxoglutarate

KW - alpha keto glutarate (AKG)

KW - osteoporoses

KW - melatonin

KW - cholesterol

KW - cancer

KW - collagen

KW - muscle

KW - artery elasticity

KW - mineral absorption

M3 - Journal article

VL - 59

SP - 91

EP - 106

JO - Journal of Physiology and Pharmacology

JF - Journal of Physiology and Pharmacology

SN - 0867-5910

IS - Suppl. 1

ER -

ID: 8113466