Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article

Research output: Contribution to journalJournal articleResearchpeer-review

Adrian Paul Harrison, S.G. Pierzynowski

The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.
Original languageEnglish
JournalJournal of Physiology and Pharmacology
Volume59
Issue numberSuppl. 1
Pages (from-to)91-106
Number of pages16
ISSN0867-5910
Publication statusPublished - 2008

    Research areas

  • LIFE - 2-oxoglutarate, alpha keto glutarate (AKG), osteoporoses, melatonin, cholesterol, cancer, collagen, muscle, artery elasticity, mineral absorption

ID: 8113466