Department of Drug Design and Pharmacology

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Published
Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study
Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2009, In : Pain Medicine. 10, 8, p. 1442-1451
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example
Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In : Journal of Biological Chemistry. 285, 36, p. 28252-28260
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design
Gloriam, David E., Foord, S. M., Blaney, F. E. & Garland, S. L., 2009, In : Journal of Medicinal Chemistry. 52, 14, p. 4429-4442
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice
Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In : Epilepsy Research. 95, 1-2, p. 70-81
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration
Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, 2012, In : Biomacromolecules. 13, p. 905-917
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Delivery technologies for biopharmaceuticals: a critical assessment
van de Weert, Marco, 2009, Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines. Jørgensen, L. & Mørck Nielsen, H. (eds.). Chichester: Wiley, p. 407-411
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
Published
Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In : Neurochemical Research. 33, 12, p. 2629-2635
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dendritiske nanostrukturer som transportører af genestisk medicin
Jensen, L. B., Nielsen, Hanne Mørck & Foged, Camilla, 2008, In : Lægemiddelforskning. p. 13-15
Research output: Contribution to journal › Journal article › Communication
Published
Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control
Haugaard, Steen Bendix, Madsbad, Sten, Mu, Huiling & Vaag, A., 2010, In : International Journal of Obesity. 34, 3, p. 500-510 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Description of aquatic ecosystem's development by eco-exergy and exergy destruction
Jørgensen, S. E., 2007, In : Ecological Modelling. 204, 1-2, p. 22-28
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design and synthesis of dimeric ligands: optimization of selectivity and potency of glutamate receptor ligands
Thorsen, B. H. K., 2009, København: Det Farmaceutiske Fakultet. 154 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction
Bach, Anders, Chi, C. N., Pang, G. F., Olsen, L., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2009, In : Angewandte Chemie - International Edition. 48, 51, p. 9685-9689
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design and synthesis of new 1-hydroxypyrazole-based ligands for characterizing the GABA_A receptor orthosteric binding site
Hansen, H. M., 2009, København: Det Farmaceutiske Fakultet. 156 p.
Research output: Book/Report › Ph.D. thesis › Research
Design and synthesis of selective serotonin receptor agonists for positron emission tomography imaging of the brain
Hansen, M., 16 Dec 2010, København: Det Farmaceutiske Fakultet. 207 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Design and synthesis of subtype selective ligands for the human excitatory amino acid transporters (EAATs) and design and synthesis of novel selective phosphodiesterase 10A (PDE10A) inhibitors
Erichsen, M. N., 2011, København: Det Farmaceutiske Fakultet. 158 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA
Jensen, D. M. K., Jensen, L. B., Koocheki, S., Cun, D., Nielsen, Hanne Mørck, Foged, Camilla & Bengtson, L., 2012, In : Journal of Controlled Release. 157, 1, p. 141-148
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin a₂ß₁receptor
Knudsen, N. Ø., Schiffelers, R. M., Jørgensen, Lene, Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In : International Journal of Pharmaceutics. 428, 1-2, p. 171-177
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design space approach in the optimization of the spray-drying process
Lebrun, P., Krier, F., Mantanus, J., Grohganz, Holger, Yang, Mingshi, Rozet, E., Boulanger, B., Evrard, B., Rantanen, Jukka & Hubert, P., 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 80, 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design, synthesis and pharmacological characterization of ligands for the neuronal nicotinic acetylcholine receptors
Hansen, C. P., 2009, København: Det Farmaceutiske Fakultet. 158 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Design, synthesis and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands
Lund, B. W., 2007, København: Det Farmaceutiske Fakultet. 197 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1
Thorn, K., Andersen, R., Christensen, J., Jacobsen, P., Nielsen, C. U., Steffansen, B. & Begtrup, M., 2007, In : ChemMedChem. 2, 4, p. 479-487
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner-Osborne, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In : Journal of Medicinal Chemistry. 53, 17, p. 6506-6510
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta² -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors
Dallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., De Amici, M., Fucile, S., Piccari, V., Frydenvang, Karla Andrea, Pucci, L., Gotti, C., Clementi, F. & De Micheli, C., 2 May 2011, In : ChemMedChem. 6, 5, p. 889-903
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor ß ligands
Lund, B. W., Knapp, A. E., Piu, F., Gauthier, N. K., Begtrup, M., Hacksell, U. & Olsson, R., 2009, In : Journal of Medicinal Chemistry. 52, 6, p. 1540-1545
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of 2,6-dichlorobenzamide and its degradation products in water samples using solid-phase exctraction followed by liquid chromatography-tandem mass spectrometry
Anskjær, G. G., Björklund, B. E., Simonsen, A. & Halling-Sørensen, B., 2009, In : Journal of Chromatography A. 1216, p. 5199-5206
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of abiotic and microbial transformation products of ivermectin
Sporring, S. H., Krogh, K. A., Jensen, G. G., Raich-Montiu, J. & Halling-Sørensen, B., 2007.
Research output: Contribution to conference › Poster › Research
Published
Determination of amorphous content in the pharmaceutical process environment
Savolainen, M., Jouppila, K., Pajamo, O., Christiansen, L., Strachan, C., Karjalainen, M. & Rantanen, Jukka, 2007, In : Journal of Pharmacy and Pharmacology. 59, 2, p. 161-170
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis
Anderot, M., Nilsson, M., Végvári, Á., Møller, E. H., van de Weert, Marco & Isaksson, R., 2009, In : Journal of Chromatography - B. 877, p. 892-896
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry
Raich-Montiu, J., Krogh, K. A., Granados, M., Jönsson, J. Å. & Halling-Sørensen, B., 2008, In : Journal of Chromatography A. 1187, 1-2, p. 275-280
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detection
Olsen, K., Hansen, S. H., Sidenius, U. & Schmiegelow, Kjeld, 2008, In : Journal of Chromatography - B. 864, 1-2, p. 149-155
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of liposome-buffer distribution coefficients of charged drugs by capillary electrophoresis frontal analysis
Franzen, U., Jørgensen, Lene, Larsen, C. S., Heegaard, N. H. H. & Østergaard, Jesper, 2009, In : Electrophoresis. 30, 15, p. 2711-2719
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?
Runnqvist, H. E. S., Bak, S. A., Hansen, M., Styrishave, Bjarne, Halling-Sørensen, B. & Björklund, B. E., 2010, In : Journal of Chromatography A. 1217, 16, p. 2447-2470
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of protein conformation by isotopically labelled cross-linking and dedicated software: Application to the chaperone, calreticulin
Nielsen, T., Thaysen-Andersen, M., Larsen, N., Jørgensen, Flemming Steen, Houen, G. & Højrup, P., 2007, In : International Journal of Mass Spectrometry. 268, 2-3, p. 217-226
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of steroid hormones in blood by GC-MS/MS
Hansen, M., Jacobsen, N. W., Nielsen, F. K., Björklund, E., Styrishave, Bjarne & Halling-Sørensen, B., 2011, In : Analytical and Bioanalytical Chemistry. 400, p. 3409-3417
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection
Zimmermann, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2007, In : Journal of Pharmaceutical and Biomedical Analysis. 44, 4, p. 874-880
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of ten steroid hormones in animal waste manure and agricultural soil using inverse and integrated clean-up pressurized liquid extraction and gas chromatography-tandem mass spectrometry
Hansen, M., Krogh, K. A., Halling-Sørensen, B. & Björklund, B. E., 2011, In : Analytical Methods. 3, p. 1087-1095
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Determination of the binding sites for oxaliplatin on insulin using mass spectrometry-based approaches
Møller, C., Sprenger, R. R., Stürup, Stefan & Højrup, P., 2011, In : Analytical and Bioanalytical Chemistry. 401, p. 1619-1629
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Developing a generic, individualised adherence programme for chronic medication users
Herborg, H., Nørgaard, Lotte Stig, Sørensen, L., Rossing, C. & Dam, P., 2008, In : Pharmacy Practice. 6, 3, p. 148-157
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism
Madsen, K. G., Olsen, J., Skonberg, C., Hansen, S. H. & Jurva, U., 2007, In : Chemical Research in Toxicology. 20, 5, p. 821-831
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development and validation of a microemulsion electrokinetic chromatography method for patulin quantification in commercial apple juice
Murillo-Arbizu, M., González-Peñas, E., Hansen, S. H., Amézqueta, S. & Østergaard, Jesper, 2008, In : Food and Chemical Toxicology. 46, 6, p. 2251-2257
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development and validation of an SPE methodology combined with LC-MS/MS for the determination of four ionophores in aqueous environmental matrices
Bak, S. A., Hansen, M., Krogh, K. A., Brandt, A., Halling-Sørensen, B. & Björklund, E., 25 Feb 2013, In : International Journal of Environmental Analytical Chemistry. 93, 14, p. 1500-1512
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development and validation of rapid resolution RP-HPLC Method for simultaneous determination of atorvastatin and related compounds by use of chemometrics
Petkovska, R., Cornett, Claus & Dimitrovska, A., 2008, In : Analytical Letters. 41, 6, p. 992-1009
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of a new rapid method for in vitro detection of pyrogenic substances
Timm, M., 2009, København: Museum Tusculanum. 65 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Development of a qualitative exploratory case study research method to explore sustained delivery of cognitive services
Kaae, Susanne, Søndergaard, B., Nørgaard, Lotte Stig & Traulsen, Janine Marie, 2010, In : Pharmacy World and Science. 32, p. 36-42
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity
Otto, M., Hansen, S. H., Dalgaard, L., Dubois, J. & Badolo, L., 2008, In : Cell Biology and Toxicology. 24, 1, p. 87-99
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of an N-O linker for fluorous phase chemistry & fluorous parallel synthesis of a piperazinedione fused tricyclic compound library
Nielsen, S. D., 2009, København: Det Farmaceutiske Fakultet. 161 p.
Research output: Book/Report › Ph.D. thesis › Research
Published
Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry
Krogh, K. A., Björklund, B. E., Loeffler, D., Fink, G., Halling-Sørensen, B. & Ternes, T. A., 2008, In : Journal of Chromatography A. 1211, 1-2, p. 60-69
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of personal desiderata while learning GIS
Madsen, Lene Møller, Christiansen, Frederik Voetmann & Rump, Camilla Østerberg, 2009, Frontiers in Science Education Research: Proceedings of the Frontiers in Science Education Research Conference 22 - 24 March 2009, Famagusta, North Cyprus. Bisel, A. & Garib, M. U. (eds.). Eastern Mediterranean University Press, p. 441-450 9 p.
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Published
Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms
Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2007, In : European Journal of Pharmaceutical Sciences. 32, 4-5, p. 261-270
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of solid-phase aziridine chemistries: Piperazine scaffolds and unnatural amino acid building blocks
Ottesen, L. K., 2010, København: Det Farmaceutiske Fakultet. 139 p.
Research output: Book/Report › Ph.D. thesis › Research

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