Research areas

  1. Published

    An in vitro assay based on surface plasmon resonance to predict the in vivo circulation kinetics of liposomes. / Crielaard, B. J.; Yousefi, A.; Schillemans, J. P.; Vermehren, C.; Buyens, K.; Braeckmans, K.; Lammers, T.; Storm, G.

    In: Journal of Controlled Release, Vol. 156, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Computeren forudsiger lægemidlers omdannelse i leveren. / Rydberg, Patrik; Olsen, Lars.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 44-46.

    Research output: Contribution to journalJournal articleCommunication

  4. Published

    Funktionelle fibriller som depotmedicin mod prostatakræft. / Jensen, Minna Grønning; van Maarschalkerweerd, Andreas; Gottschalk, Tine.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 20-22.

    Research output: Contribution to journalJournal articleCommunication

  5. Published

    Gendannelse af ødelagt væv med stamceller. / Møller, Eva Horn; Wen, Yanhong; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 13-15.

    Research output: Contribution to journalJournal articleCommunication

  6. Published

    Genetisk nanomedicin til behandling af leddegigt. / Foged, Camilla; Jensen, Linda Boye; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, 12.2011, p. 7-9.

    Research output: Contribution to journalJournal articleCommunication

  7. Published

    Massespektrometri viser fordelingen af lægemiddelstoffer i planter og væv. / Janfelt, Christian; Thunig, Janina; Li, Bin; Andersen, Niels Wellner; Hansen, Harald S.; Hansen, Steen Honore'.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 10-12.

    Research output: Contribution to journalJournal articleCommunication

  8. Published

    Medicinalplanter og abort : ny viden kan hjælpe afrikanske kvinder. / Jäger, Anna; Kristiansen, Uffe; Rasch, Vibeke.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 23-25.

    Research output: Contribution to journalJournal articleCommunication

  9. Published

    Målrettet fisketur i hjernen giver ny viden om Fantasys virkningssted. / Villumsen, Inge Stengaard; Vogensen, Stine Byskov; Frølund, Bente; Clausen, Rasmus Prætorius; Wellendorph, Petrine.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 26-28.

    Research output: Contribution to journalJournal articleCommunication

  10. Published

    Nanobodies fra kameler - En ny klasse antistoffer til diagnostik og behandling. / Skottrup, Peter Durand; Clausen, Rasmus Prætorius; Riise, Erik .

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 4-6.

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    From retrospective assessment to prospective decisions in natural product isolation : HPLC-SPE-NMR analysis of Carthamus oxyacantha. / Johansen, Kenneth T; Wubshet, Sileshi G; Nyberg, Nils T; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 74, No. 11, 28.11.2011, p. 2454-2461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Small molecules from spiders used as chemical probes. / Olsen, Christian Adam; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Angewandte Chemie International Edition, Vol. 50, No. 48, 25.11.2011, p. 11296-11311.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. / Gloriam, David E.; Wellendorph, Petrine; Johansen, Lars Dan; Thomsen, Alex Rojas Bie; Phonekeo, Karina; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Chemistry & Biology, Vol. 18, No. 11, 23.11.2011, p. 1489-1498.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Amino triazolo diazepines (Ata) as constrained histidine mimics. / Buysse, Koen; Farard, Julien; Nikolaou, Alexandros; Vanderheyden, Patrick; Vauquelin, Georges; Pedersen, Daniel Sejer; Tourwé, Dirk; Ballet, Steven .

    In: Organic Letters, Vol. 13, No. 24, 16.11.2011, p. 6468-6471.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    Scientific social responsibility : a call to arms. / Krogsgaard-Larsen, Povl; Thostrup, Peter; Besenbacher, Flemming.

    In: Angewandte Chemie International Edition, Vol. 50, No. 46, 11.11.2011, p. 10738-10740.

    Research output: Contribution to journalComment/debateResearch

  16. Published

    Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2. / Mikkelsen, Lone; Sheykhzade, Majid; Jensen, Keld A; Saber, Anne T; Jacobsen, Nicklas R.; Vogel, Ulla Birgitte; Wallin, Håkan; Loft, Steffen; Møller, Peter.

    In: Particle and Fibre Toxicology, Vol. 8, No. 1, 10.11.2011, p. 32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Alleviation of nociception in rats by treatment with ceftriaxone, a ß-lactam that promote the expression of the excitatory amino acid transporter 2. / Bjerrum, Ole Jannik; Abrahamsen, Bjarke; Honoré, Per Gustaf Hartvig.

    2011. Poster session presented at Share Symposium 2010, Copenhagen, Denmark.

    Research output: Contribution to conferencePosterCommunication

  18. Published

    Pharmacological and physiological studies of the calcium-sensing receptor. / Thomsen, Alex Rojas Bie.

    København : Det Farmaceutiske Fakultet, 2011. 89 p.

    Research output: Book/ReportPh.D. thesisResearch

  19. Published

    SDF2XYZ2SDF : how to exploit TINKER power in cheminformatics projects. / Tosco, Paolo; Balle, Thomas; Shiri, Fereshteh.

    In: Journal of Molecular Modeling, Vol. 17, No. 11, 11.2011, p. 3021-3023.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Antimicrobial evaluation of Huilliche plant medicine used to treat wounds. / Mølgaard, Per; Holler, Jes Gitz; Asar, Betül; Liberna, Iwona; Rosenbæk, Lise Bakkestrøm; Jebjerg, Christina Ploug; Jørgensen, Lene; Lauritzen, Jeanette ; Guzman, Alfonso; Adsersen, Anne; Simonsen, Henrik Toft.

    In: Journal of Ethnopharmacology, Vol. 138, No. 1, 31.10.2011, p. 219-227.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Antifungal metabolites from fungal endophytes of Pinus strobus. / Sumarah, Mark W; Kesting, Julie R; Sørensen, Dan; Miller, J David.

    In: Phytochemistry, Vol. 72, No. 14-15, 01.10.2011, p. 1833-1837.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Stress and medicine use for headache: does sense of coherence modify the association? / Koushede, Vibeke Jenny; Holstein, Bjørn E; Andersen, Anette; Hansen, Ebba Holme.

    In: European Journal of Public Health, Vol. 21, No. 5, 01.10.2011, p. 656-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. / Mahmmoud, Yasser Ahmed; Christensen, Søren Brøgger.

    In: BBA General Subjects, Vol. 1808, No. 10, 10.2011, p. 2413-2420.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The calcium-sensing receptor and calcimimetics in blood pressure modulation. / Smajilovic, Sanela; Yano, Shozo; Jabbari, Reza; Tfelt-Hansen, Jacob.

    In: British Journal of Pharmacology, Vol. 164, No. 3, 10.2011, p. 884-893.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Metabolic profiling based on two-dimensional J-resolved 1H NMR data and parallel factor analysis. / Yilmaz, Ali; Nyberg, Nils T; Jaroszewski, Jerzy W.

    In: Analytical Chemistry, Vol. 83, No. 21, 27.09.2011, p. 8278-8285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Production of unusual dispiro metabolites in Pestalotiopsis virgatula endophyte cultures : HPLC-SPE-NMR, electronic circular dichroism, and time-dependent density-functional computation study. / Kesting, Julie Regitze; Olsen, Lars; Stærk, Dan; Tejesvi, Mysore V; Kini, Kukkundoor R; Prakash, Harishchandra S; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 74, No. 10, 26.09.2011, p. 2206-2215.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2. / Nielsen, Simon Dalsgaard; Fulco, Marica; Serpi, Michaela; Nielsen, Birgitte; Hansen, Maria Brinck ; Hansen, Kasper Lind; Thomsen, Christian; Brodbeck, Robb; Bräuner-Osborne, Hans; Pellicciari, Roberto; Norrby, Per-Ola; Greenwood, Jeremy R; Clausen, Rasmus Prætorius.

    In: MedChemComm, Vol. 2, No. 11, 23.09.2011, p. 1120-1124.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors. / Lohse, Brian; Nielsen, Anders L; Kristensen, Jan B L; Helgstrand, Charlotte; Cloos, Paul Andreas Compare; Olsen, Lars; Gajhede, Michael; Clausen, Rasmus Prætorius; Kristensen, Jesper Langgaard.

    In: Angewandte Chemie International Edition, Vol. 50, No. 39, 19.09.2011, p. 9100-9103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats. / Stefkov, Gjoshe; Kulevanova, Svetlana; Miova, Biljana; Dinevska-Kjovkarovska, Suzana; Mølgaard, Per; Jäger, Anna K; Josefsen, Knud.

    In: Pharmaceutical Biology, Vol. 49, No. 9, 01.09.2011, p. 885-892.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons. / Dadsetan, Sherry; Bak, Lasse Kristoffer; Sørensen, Michael; Keiding, Susanne; Vilstrup, Hendrik; Ott, Peter; Leke, Renata; Schousboe, Arne; Waagepetersen, Helle S.

    In: Neurochemistry International, Vol. 59, No. 4, 01.09.2011, p. 482-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Ubiquitous plant compounds disturb cell-based assays. / Saaby, Lasse; Jäger, Anna K.

    In: Journal of Ethnopharmacology, Vol. 137, No. 1, 01.09.2011, p. 942-943.

    Research output: Contribution to journalComment/debateResearchpeer-review

  33. Published

    Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model. / Rasmussen, Rune Skovgaard; Overgaard, Karsten; Kristiansen, Uffe; Johansen, Flemming Fryd.

    In: Neurological Research, Vol. 33, No. 7, 09.2011, p. 774-782.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Do two different reaction mechanisms contribute to the hydroxylation of primary amines by cytochrome P450? / Rydberg, Patrik; Olsen, Lars.

    In: Journal of Chemical Theory and Computation, Vol. 7, No. 10, 09.2011, p. 3399-3404.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Evolution and applications of plant pathway resources and databases. / Sucaet, Yves; Deva, Taru.

    In: Briefings in Bioinformatics, Vol. 12, No. 5, 09.2011, p. 530-544.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The spared nerve injury (SNI) model of induced mechanical allodynia in mice. / Richner, Mette; Bjerrum, Ole Jannik; Nykjær, Anders; Vaegter, Christian B.

    In: Journal of Visualized Experiments, No. 54, 18.08.2011, p. e3092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects. / Dam, Gitte; Keiding, Susanne; Munk, Ole Lajord; Ott, Peter; Buhl, Mads; Vilstrup, Hendrik; Bak, Lasse Kristoffer; Waagepetersen, Helle Sønderby; Schousboe, Arne; Møller, Niels; Sørensen, Michael.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 301, No. 2, 01.08.2011, p. G269-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression : comparison with sertraline. / Andreasen T., Jesper; Henningsen, Kim; Bate, Simon; Christiansen, Sofie; Wiborg, Ove.

    In: Journal of Psychopharmacology, Vol. 25, No. 8, 01.08.2011, p. 1134-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    ß-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons. / Lund, Trine Meldgaard; Obel, Linea F; Risa, Øystein; Sonnewald, Ursula.

    In: Neurochemistry International, Vol. 59, No. 2, 01.08.2011, p. 309-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Extraction and detection of Ionophores in the Aquatic Environment. / Bak, Søren Alex; Hansen, Martin; Krogh, Kristine Andersen; Björklund, Erland; Halling-Sørensen, Bent.

    2011. Abstract from 3rd EmCon 2011: International conference on analysis of emerging contaminants in the environment, Copenhagen, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  41. Published

    Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging. / Ostergaard, Jesper; Ye, Fengbin; Rantanen, Jukka; Yaghmur, Anan; Larsen, Susan Weng; Larsen, Claus Selch; Jensen, Henrik.

    In: Journal of Pharmaceutical Sciences, Vol. 100, No. 8, 08.2011, p. 3405-3410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1. / Thorn, Karina; Nielsen, Carsten Uhd; Jakobsen, Palle; Steffansen, Bente; Zercher, Charles K; Begtrup, Mikael.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 21, No. 15, 08.2011, p. 4597-4601.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Open3DALIGN : an open-source software aimed at unsupervised ligand alignment. / Tosco, Paolo; Balle, Thomas; Shiri, Fereshteh.

    In: Journal of Computer - Aided Molecular Design, Vol. 25, No. 8, 27.07.2011, p. 777-783.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors. / Harpsøe, Kasper; Ahring, Philip K; Christensen, Jeppe K; Jensen, Marianne L; Peters, Dan; Balle, Thomas.

    In: Journal of Neuroscience, Vol. 31, No. 30, 27.07.2011, p. 10759-10766.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    RS-predictor : a new tool for predicting sites of cytochrome P450-mediated metabolism applied to CYP 3A4. / Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik; Huang, Tao-wei; Bennett, Kristin P; Breneman, Curt M.

    In: Journal of Chemical Information and Modeling, Vol. 51, No. 7, 25.07.2011, p. 1667-1689.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines. / Nielsen, Simon Dalsgaard; Smith, Garrick P; Begtrup, Mikael; Kristensen, Jesper Langgaard.

    In: Tetrahedron, Vol. 67, No. 29, 22.07.2011, p. 5261-5267.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. / Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda; Toubro, Søren; Hansen, Stinna Maria R; Eildal, Jonas Nii Nortey; Bond, Andrew D; Bøgesø, Klaus P; Bang-Andersen, Benny; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 29, 19.07.2011, p. 12137-12142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. / Madsen, Karsten Kirkegaard; Ebert, Bjarke; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl; Schousboe, Arne; White, H Steve.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 338, No. 1, 01.07.2011, p. 214-219.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Temocene: the porphycene analogue of temoporfin (Foscan®). / Garcia-Diaz, Maria; Sanchez-Garcia, David; Nonell, Santi; Soriano, Jorge; Villanueva, Angeles; Stockert, Juan Carlos; Canete, Magdalena; Sagrista, Maria Lluisa; Mora, Margarita.

    In: MedChemComm, Vol. 2, No. 7, 01.07.2011, p. 616-619.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Chemical composition and biological screening of Capsella bursa-pastoris. / Grosso, Clara; Vinholes, Juliana; Silva, Luis R; Guedes de Pinho, Paula; Goncalves, Rui F; Valentao, Patricia; Jäger, Anna K; Andrade, Paula B.

    In: Revista Brasileira de Farmacognosia, Vol. 21, No. 4, 07.2011, p. 635-644.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Direct on-line monitoring of methylseleninic acid metabolism in hepatocytes using membrane inlet mass spectrometry. / Bak, Søren Alex; Hansen, Helle Rüsz; Badolo, Lassina; Lauritsen, Frants Roager.

    2011. Poster session presented at DanSAK9, Danish Symposium for Analytical Chemistry, Lyngby, Denmark.

    Research output: Contribution to conferencePosterResearch

  52. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.

    In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras : influence of amino acid composition and chain length on the activity against different bacterial strains. / Hein-Kristensen, Line; Knapp, Kolja Michael; Franzyk, Henrik; Gram, Lone.

    In: B M C Microbiology, Vol. 11, No. 1, 22.06.2011, p. 144.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. / Lehre, A C; Rowley, N M; Zhou, Y; Holmseth, S; Guo, C; Holen, T; Hua, R; Laake, P; Olofsson, A M; Poblete-Naredo, I; Rusakov, D A; Madsen, Karsten Kirkegaard; Clausen, Rasmus Prætorius; Schousboe, Arne; White, H Steve; Danbolt, N C.

    In: Epilepsy Research, Vol. 95, No. 1-2, 01.06.2011, p. 70-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. / Kristensen, Anders Skov; Jenkins, Meagan A; Banke, Tue G; Schousboe, Arne; Makino, Yuichi; Johnson, Richard C; Huganir, Richard; Traynelis, Stephen F.

    In: Nature Neuroscience, Vol. 14, No. 6, 01.06.2011, p. 727-735.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy. / Leke, Renata; Bak, Lasse Kristoffer; Iversen, Peter; Sørensen, Michael; Keiding, Susanne; Vilstrup, Hendrik; Ott, Peter; Portela, Luis V; Schousboe, Arne; Waagepetersen, Helle S.

    In: Journal of Neurochemistry, Vol. 117, No. 5, 01.06.2011, p. 824-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    In silico predictions of hERG channel blockers in drug discovery : from ligand-based and target-based approaches to systems chemical biology. / Taboureau, Olivier; Jørgensen, Flemming Steen.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 14, No. 5, 06.2011, p. 375-387.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. / Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D.

    In: Journal of Biological Chemistry, Vol. 286, No. 20, 20.05.2011, p. 17569-17578.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP). / Sooriyaarachchi, Sanjeewani; Jaber, Emad; Covarrubias, Adrian Suárez; Ubhayasekera, Wimal; Asiegbu, Frederick O; Mowbray, Sherry L.

    In: Plant Molecular Biology, Vol. 77, No. 1-2, 17.05.2011, p. 33-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Extraction and detection of Ionophores in the Aquatic Environment. / Bak, Søren Alex; Hansen, Martin; Krogh, Kristine Andersen; Björklund, Erland; Halling-Sørensen, Bent.

    2011. Poster session presented at 21th SETAC Europe, Milan, Italy.

    Research output: Contribution to conferencePosterResearch

  61. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases. / Vandecaetsbeek, Ilse; Christensen, Søren Brøgger; Liu, Huizhen; van Veldhoven, Paul P; Waelkens, Etienne; Eggermont, Jan; Raeymaekers, Luc; Møller, Jesper V; Nissen, Poul; Wuytack, Frank; Vangheluwe, Peter.

    In: BBA General Subjects, Vol. 1813, No. 5, 01.05.2011, p. 1118-1127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    1,2,3-triazoles in peptidomimetic chemistry. / Pedersen, Daniel Sejer; Abell, Andrew.

    In: European Journal of Organic Chemistry, Vol. 2011, No. 13, 05.2011, p. 2399-2411.

    Research output: Contribution to journalReviewResearchpeer-review

  64. Published

    New insights into the GABAA receptor structure and orthosteric ligand binding : Receptor modeling guided by experimental data. / Sander, Tommy; Frølund, Bente Flensborg; Bruun, Anne Techau; Ivanov, Ivaylo; McCammon, James Andrew; Balle, Thomas.

    In: Proteins: Structure, Function, and Bioinformatics, Vol. 79, No. 5, 05.2011, p. 1458-1477.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Studies of monoamine transporters : Phosphorylation of the serotonin transporter and interactions of antidepressants with the serotonin and norepinephrine transporters. / Sørensen, Lena.

    København : Det Farmaceutiske Fakultet, 2011. 174 p.

    Research output: Book/ReportPh.D. thesisResearch

  66. Published

    X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase. / Yennawar, Hemant; Møller, Magda; Gillilan, Richard; Yennawar, Neela.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 67, No. Pt 5, 05.2011, p. 440-446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital in human volunteers. / Lappin, Graham ; Shishikura, Yoko; Jochemsen, Roeline; Weaver, Richard John ; Gesson, Charlotte; Houston, J. Brian ; Oosterhuis, Berend; Bjerrum, Ole Jannik; Grynkiewicz, Grzegorz; Alder, Jane; Rowland, Malcolm; Garner, Colin.

    In: European Journal of Pharmaceutical Sciences, Vol. 43, No. 3, 20.04.2011, p. 141-150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Pharmacological properties of Anagallis arvensis L. ("scarlet pimpernel") and Anagallis foemina Mill. ("blue pimpernel") traditionally used as wound healing remedies in Navarra (Spain). / López, Víctor; Jäger, Anna Katharina; Akerreta, Silvia; Cavero, Rita Yolanda; Calvo, Maria Isabel.

    In: Journal of Ethnopharmacology, Vol. 134, No. 3, 12.04.2011, p. 1014-1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Electrophilic organic selenium reagents : protonated seleninic acids as precursors for unsymmetrical aromatic selenides. / Stuhr-Hansen, Nicolai; Sølling, Theis Ivan; Henriksen, Lars.

    In: Tetrahedron, Vol. 67, No. 14, 08.04.2011, p. 2633-2643.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    ZP2307, a novel cyclic PTH(1-17) analog, reversed established osteopenia in adult ovariectomized rats. / Vääräniemi, Jukka; Morko, Jukka ; Peng, ZhiQi; Rissanen, Jukka P ; Suominen, Mari I; Fagerlund, Katja M; Suutari, Tiina A; Boonen, Harrie C.M.; Neerup, Trine SR; Bak, Hanne H ; Halleen, Jussi M .

    2011. Poster session presented at 3rd Joint meeting of the European Calcified Tissue Society and International Bone and Mineral Society, Athens, Greece.

    Research output: Contribution to conferencePosterResearch

  71. Published

    Discovery of benzamide analogues as a novel class of 5-HT3 receptor agonists. / Jørgensen, Charlotte Grube; Frølund, Bente Flensborg; Kehler, Jan; Jensen, Anders Asbjørn.

    In: ChemMedChem, Vol. 6, No. 4, 04.04.2011, p. 725-736.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity. / Søvsø Jensen, Bent; Christensen, Søren Brøgger; Jäger, Anna Katharina; Rønsted, Nina Astrid Helene.

    In: Biochemical Systematics and Ecology, Vol. 39, No. 2, 04.2011, p. 153-155.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Glutamate receptor agonists : stereochemical aspects. / Vogensen, Stine Byskov; Greenwood, Jeremy R; Bunch, Lennart; Clausen, Rasmus Prætorius.

    In: Current Topics in Medicinal Chemistry, Vol. 11, No. 7, 04.2011, p. 887-906.

    Research output: Contribution to journalReviewResearchpeer-review

  74. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. / Bach, Anders*; Eildal, Jonas Nii Nortey*; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Søren Wittrup; Kristensen, Anders Skov; Strømgaard, Kristian (*Shared 1st authors).

    In: Journal of Medicinal Chemistry, Vol. 54, No. 5, 10.03.2011, p. 1333-1346.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    European new safe and innovative medicines initiatives : history and progress (through December 2009). / Bjerrum, Ole Jannik; H. Linden, Hans.

    Translational medicine and drug discovery. Cambridge : Cambridge University Press, 2011. p. 265-288.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  76. Published

    Metabolic profiling of Rhodiola rosea rhizomes by 1H NMR spectroscopy. / Ioset, Karine Ndjoko; Nyberg, Nils T; Van Diermen, Daphne; Malnoe, Pia; Hostettmann, Kurt; Shikov, Alexander N; Jaroszewski, Jerzy W.

    In: Phytochemical Analysis, Vol. 22, No. 2, 03.2011, p. 158-165.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations. / Ísberg, Vignir; Balle, Thomas; Sander, Tommy; Jørgensen, Flemming Steen; Gloriam, David Erik Immanuel.

    In: Journal of Chemical Information and Modeling, Vol. 51, No. 2, 28.02.2011, p. 315-325.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp. / Runager, Kasper; Basaiawmoit, Rajiv Vaid; Deva, Taru; Andreasen, Maria; Valnickova, Zuzana; Sørensen, Charlotte S; Karring, Henrik; Thøgersen, Ida B; Christiansen, Gunna; Underhaug, Jarl; Kristensen, Torsten; Nielsen, Niels Chr; Klintworth, Gordon K; Otzen, Daniel E; Enghild, Jan J.

    In: The Journal of Biological Chemistry, Vol. 286, No. 7, 18.02.2011, p. 4951-4958.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Medicinal chemistry of competitive kainate receptor antagonists. / Larsen, Ann M; Bunch, Lennart.

    In: ACS Chemical Neuroscience, Vol. 2, No. 2, 16.02.2011, p. 60-74.

    Research output: Contribution to journalReviewResearchpeer-review

  80. Published

    Flavonoids and the CNS. / Jäger, Anna Katharina; Saaby, Lasse.

    In: Molecules, Vol. 16, No. 2, 10.02.2011, p. 1471-1485.

    Research output: Contribution to journalReviewResearchpeer-review

  81. Published

    Functional and structural studies of neuronal D-serine transporter Asc1. / Wang, Xiaole.

    København : Det Farmaceutiske Fakultet, 2011. 148 p.

    Research output: Book/ReportPh.D. thesisResearch

  82. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics. / Bach, Anders; Strømgaard, Kristian.

    In: Synthesis, Vol. 2011, No. 5, 08.02.2011, p. 807-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. / Chi, Celestine Ngang; Bach, Anders; Engström, Åke; Strømgaard, Kristian; Lundström, Patrik; Ferguson, Neil; Jemth, Per.

    In: Journal of Biological Chemistry, Vol. 286, No. 5, 04.02.2011, p. 3597-3606.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. / Pinto, Andrea; Conti, Paola; Grazioso, Giovanni; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; De Micheli, Carlo.

    In: European Journal of Medicinal Chemistry, Vol. 46, No. 2, 01.02.2011, p. 787-793.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published
  86. Published

    Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). / Saaby, Lasse; Jäger, Anna Katharina; Moesby, Lise; Hansen, Erik Wind; Christensen, Søren Brøgger.

    In: Phytotherapy Research, Vol. 25, No. 2, 02.2011, p. 195-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. / Hornbak, Malene; Banasik, Karina; Justesen, Johanne Marie; Krarup, Nikolaj Thure; Sandholt, Camilla Helene; Andersson, Åsa; Sandbaek, Annelli; Lauritzen, Torsten; Pisinger, Charlotta; Witte, Daniel R; Sørensen, Thorkild I.A.; Pedersen, Oluf; Hansen, Torben.

    In: BMC Medical Genetics, Vol. 12, No. 1, 06.01.2011, p. 4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. / Pøhlsgaard, Jacob; Frydenvang, Karla Andrea; Madsen, Ulf; Kastrup, Jette Sandholm.

    In: Neuropharmacology, Vol. 60, No. 1, 01.01.2011, p. 135-150.

    Research output: Contribution to journalReviewResearchpeer-review

  89. Published

    Potentiating action of propofol at GABAA receptors of retinal bipolar cells. / Yue, Lan; Xie, An; Bruzik, Karol S; Frølund, Bente Flensborg; Qian, Haohua; Pepperberg, David R.

    In: Investigative Ophthalmology & Visual Science, Vol. 52, No. 5, 01.01.2011, p. 2497-2509.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Purification, crystallization and preliminary X-ray diffraction of the G3BP1 NTF2-like domain. / Vognsen, Tina; Möller, Ingvar Rúnar; Kristensen, Ole.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 67, No. Pt 1, 01.01.2011, p. 48-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors. / Nilsson, Jakob; Gidlöf, Ritha; Nielsen, Elsebet Østergaard; Liljefors, Tommy; Nielsen, Mogens Peter Cherly; Sterner, Olov.

    In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 1, 01.01.2011, p. 111-121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Effects of bile on the oral absorption of poorly water-soluble drugs in rats. / Tønsberg, Henrik.

    København : Det Farmaceutiske Fakultetsbibliotek, Det Farmaceutiske Fakultet, Københavns Universitet, 2011. 83 p.

    Research output: Book/ReportPh.D. thesisResearch

  93. Published

    On-chip electro membrane extraction with online ultaviolet and mass spectrometric detection. / Petersen, Nickolaj Jacob; Foss, Sunniva Taule; Jensen, Henrik; Hansen, Steen Honore'; Skonberg, Christian; Snakenborg, Detlef; Kutter, Jörg P.; Pedersen-Bjergaard, Stig.

    In: Analytical Chemistry, Vol. 83, No. 1, 01.2011, p. 44-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    (Eco)teoxicological effects of transformation products: (Not) a research question ? / Hansen, Martin.

    2011.

    Research output: Working paperResearch

  95. Published

    1H NMR- and HPLC-based metabolomics combined with hyphenated HPLC-SPE-NMR methods for the investigation of herbal remedies and medicinal plants. / Agnolet, Sara.

    København : Det Farmaceutiske Fakultet, 2011.

    Research output: Book/ReportPh.D. thesisResearch

  96. Published

    2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. / Hansen, Katrine B; Rosenkilde, Mette M; Knop, Filip K; Wellner, Niels; Diep, Thi A; Rehfeld, Jens F; Andersen, Ulrik B; Holst, Jens J; Hansen, Harald S.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 9, 2011, p. E1409-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin. / Jensen, Linda Boye; Petersson, K.; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 79, No. 1, 2011, p. 68-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    A ligand's view of target similarity : chemogenomic binding site-directed techniques for drug discovery. / Garland, Stephen L; Gloriam, David E.

    In: Current Topics in Medicinal Chemistry, Vol. 11, No. 15, 2011, p. 1872-1881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    A model on the carbon cycling in Lake Taihu, China. / Weiping, Hu; Jørgensen, Sven Erik; Fabing, Zhang; Yonggen, Chen; Zhixin, Hu; Longyuan, Yang.

    In: Ecological Modelling, Vol. 222, No. 16, 2011, p. 2973-2991.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs. / Holm, René; Jørgensen, Erling Bonne; Harborg, Michael; Larsen, Rune Søren; Holm, Per; Müllertz, Anette; Jacobsen, Jette.

    In: European Journal of Pharmaceutical Sciences, Vol. 42, 2011, p. 416-422.

    Research output: Contribution to journalJournal articleResearchpeer-review

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