Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Research output: Contribution to journal › Journal article › Research › peer-review
- Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of amaryllidaceae
Final published version, 1.57 MB, PDF document
Nina Rønsted, Matthew R. E. Symonds, Trine Birkholm, Søren Brøgger Christensen, Alan W. Meerow, Marianne Molander Schmidt, Per Mølgaard, Gitte Petersen, Nina Rasmussen, Johannes van Staden, Gary Ivan Stafford, Anna Jäger
Results: We produced a phylogenetic hypothesis for the medicinally important plant subfamily Amaryllidoideae (Amaryllidaceae) based on parsimony and Bayesian analysis of nuclear, plastid, and mitochondrial DNA sequences of over 100 species. We tested if alkaloid diversity and activity in bioassays related to the central nervous system are significantly correlated with phylogeny and found evidence for a significant phylogenetic signal in these traits, although the effect is not strong.
Conclusions: Several genera are non-monophyletic emphasizing the importance of using phylogeny for interpretation of character distribution. Alkaloid diversity and in vitro inhibition of acetylcholinesterase (AChE) and binding to the serotonin reuptake transporter (SERT) are significantly correlated with phylogeny. This has implications for the use of phylogenies to interpret chemical evolution and biosynthetic pathways, to select candidate taxa for lead discovery, and to make recommendations for policies regarding traditional use and conservation priorities.
|Journal||BMC Evolutionary Biology|
|Number of pages||12|
|Publication status||Published - 14 Sep 2012|
Number of downloads are based on statistics from Google Scholar and www.ku.dk