Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

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Nora Elisabeth Zois, Sophia Gry Moesgaard, Mads Kjelgaard-Hansen, Caroline Elisabeth Rasmussen, Bo Torkel Falk, Christine Fossing, Jens Häggström, Henrik Duelund Pedersen, Lisbeth Høier Olsen

Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte–macrophage colony-stimulating factor, interferon-c, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-c-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.
CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in
CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.
Original languageEnglish
JournalVeterinary Journal
Volume192
Issue number1
Pages (from-to)106-111
Number of pages6
ISSN1090-0233
DOIs
Publication statusPublished - 2012

ID: 37640309