Class C G protein-coupled receptors: reviving old couples with new partners

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Documents

Thor C Møller, David Moreno-Delgado, Jean-Philippe Pin, Julie Kniazeff

G protein-coupled receptors (GPCRs) are key players in cell communication and are encoded by the largest family in our genome. As such, GPCRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPCRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPCRs, the class F includes the frizzled receptors, and the class C includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. Class C receptors are far more complex than other GPCRs, being mandatory dimers, with each subunit being composed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class C GPCRs, and how this brings information for many other GPCRs.

Original languageEnglish
JournalBiophysics reports
Volume3
Issue number4
Pages (from-to)57-63
Number of pages7
ISSN2364-3439
DOIs
Publication statusPublished - 2017
Externally publishedYes

ID: 200178138