Class C G protein-coupled receptors: reviving old couples with new partners
Research output: Contribution to journal › Journal article › Research › peer-review
Final published version, 795 KB, PDF document
Thor C Møller, David Moreno-Delgado, Jean-Philippe Pin, Julie Kniazeff
G protein-coupled receptors (GPCRs) are key players in cell communication and are encoded by the largest family in our genome. As such, GPCRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPCRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPCRs, the class F includes the frizzled receptors, and the class C includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. Class C receptors are far more complex than other GPCRs, being mandatory dimers, with each subunit being composed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class C GPCRs, and how this brings information for many other GPCRs.
|Number of pages||7|
|Publication status||Published - 2017|