Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. / Tiedemann, Daniel; Mouhammad, Zaynab A.; Utheim, Tor P.; Dartt, Darlene A.; Heegaard, Steffen; Petrovski, Goran; Kolko, Miriam.

In: Journal of Glaucoma, Vol. 28, No. 4, 01.04.2019, p. 325-333.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Tiedemann, D, Mouhammad, ZA, Utheim, TP, Dartt, DA, Heegaard, S, Petrovski, G & Kolko, M 2019, 'Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment', Journal of Glaucoma, vol. 28, no. 4, pp. 325-333. https://doi.org/10.1097/IJG.0000000000001168

APA

Tiedemann, D., Mouhammad, Z. A., Utheim, T. P., Dartt, D. A., Heegaard, S., Petrovski, G., & Kolko, M. (2019). Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. Journal of Glaucoma, 28(4), 325-333. https://doi.org/10.1097/IJG.0000000000001168

Vancouver

Tiedemann D, Mouhammad ZA, Utheim TP, Dartt DA, Heegaard S, Petrovski G et al. Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. Journal of Glaucoma. 2019 Apr 1;28(4):325-333. https://doi.org/10.1097/IJG.0000000000001168

Author

Tiedemann, Daniel ; Mouhammad, Zaynab A. ; Utheim, Tor P. ; Dartt, Darlene A. ; Heegaard, Steffen ; Petrovski, Goran ; Kolko, Miriam. / Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. In: Journal of Glaucoma. 2019 ; Vol. 28, No. 4. pp. 325-333.

Bibtex

@article{b8469f0536a74864ba3bb9532742a7e3,
title = "Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment",
abstract = "Glaucoma is the leading cause of irreversible blindness worldwide. Although no definitive cure exists, lowering of the intraocular pressure decreases the rate of progression in the majority of patients with glaucoma. Antiglaucomatous treatment modalities consist predominantly of chronic use of eye drops. It has become increasingly evident that long-term exposure to eye drops has a significant impact on the ocular surface, and thereby on patient compliance and quality of life. Maintenance of the ocular surface is highly dependent on a stable tear film. Conjunctival goblet cells (GCs) of the ocular surface play an important role in providing the innermost mucin layer of the tear film and are essential for maintaining the ocular surface homeostasis. Recent studies have reported severe side effects of antiglaucomatous drops on GCs. In particular, a preservative containing antiglaucomatous drops have been shown to affect the viability and functions of the GCs. Furthermore, GC density has been suggested as a potential predictor of surgical outcome after filtration surgery. The present review provides an overview of the current literature on the impact of antiglaucomatous eye drops on GCs as well as the impact on the ocular surface. Moreover, the existing evidence of a possible association between GC density and glaucoma filtration surgery outcome is summarized. We conclude that prostaglandin analogs spare the conjunctival GCs more compared with other antiglaucomatous drops and that GCs may be a good predictor of surgical outcome after filtration surgery. Overall, given the multiple functions of GCs in the ocular surface homeostasis, dedicated strategies should be adopted to preserve this cell population during the course of glaucoma.",
keywords = "filtration surgery, glaucoma, goblet cells, preservatives",
author = "Daniel Tiedemann and Mouhammad, {Zaynab A.} and Utheim, {Tor P.} and Dartt, {Darlene A.} and Steffen Heegaard and Goran Petrovski and Miriam Kolko",
year = "2019",
month = "4",
day = "1",
doi = "10.1097/IJG.0000000000001168",
language = "English",
volume = "28",
pages = "325--333",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment

AU - Tiedemann, Daniel

AU - Mouhammad, Zaynab A.

AU - Utheim, Tor P.

AU - Dartt, Darlene A.

AU - Heegaard, Steffen

AU - Petrovski, Goran

AU - Kolko, Miriam

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Glaucoma is the leading cause of irreversible blindness worldwide. Although no definitive cure exists, lowering of the intraocular pressure decreases the rate of progression in the majority of patients with glaucoma. Antiglaucomatous treatment modalities consist predominantly of chronic use of eye drops. It has become increasingly evident that long-term exposure to eye drops has a significant impact on the ocular surface, and thereby on patient compliance and quality of life. Maintenance of the ocular surface is highly dependent on a stable tear film. Conjunctival goblet cells (GCs) of the ocular surface play an important role in providing the innermost mucin layer of the tear film and are essential for maintaining the ocular surface homeostasis. Recent studies have reported severe side effects of antiglaucomatous drops on GCs. In particular, a preservative containing antiglaucomatous drops have been shown to affect the viability and functions of the GCs. Furthermore, GC density has been suggested as a potential predictor of surgical outcome after filtration surgery. The present review provides an overview of the current literature on the impact of antiglaucomatous eye drops on GCs as well as the impact on the ocular surface. Moreover, the existing evidence of a possible association between GC density and glaucoma filtration surgery outcome is summarized. We conclude that prostaglandin analogs spare the conjunctival GCs more compared with other antiglaucomatous drops and that GCs may be a good predictor of surgical outcome after filtration surgery. Overall, given the multiple functions of GCs in the ocular surface homeostasis, dedicated strategies should be adopted to preserve this cell population during the course of glaucoma.

AB - Glaucoma is the leading cause of irreversible blindness worldwide. Although no definitive cure exists, lowering of the intraocular pressure decreases the rate of progression in the majority of patients with glaucoma. Antiglaucomatous treatment modalities consist predominantly of chronic use of eye drops. It has become increasingly evident that long-term exposure to eye drops has a significant impact on the ocular surface, and thereby on patient compliance and quality of life. Maintenance of the ocular surface is highly dependent on a stable tear film. Conjunctival goblet cells (GCs) of the ocular surface play an important role in providing the innermost mucin layer of the tear film and are essential for maintaining the ocular surface homeostasis. Recent studies have reported severe side effects of antiglaucomatous drops on GCs. In particular, a preservative containing antiglaucomatous drops have been shown to affect the viability and functions of the GCs. Furthermore, GC density has been suggested as a potential predictor of surgical outcome after filtration surgery. The present review provides an overview of the current literature on the impact of antiglaucomatous eye drops on GCs as well as the impact on the ocular surface. Moreover, the existing evidence of a possible association between GC density and glaucoma filtration surgery outcome is summarized. We conclude that prostaglandin analogs spare the conjunctival GCs more compared with other antiglaucomatous drops and that GCs may be a good predictor of surgical outcome after filtration surgery. Overall, given the multiple functions of GCs in the ocular surface homeostasis, dedicated strategies should be adopted to preserve this cell population during the course of glaucoma.

KW - filtration surgery

KW - glaucoma

KW - goblet cells

KW - preservatives

U2 - 10.1097/IJG.0000000000001168

DO - 10.1097/IJG.0000000000001168

M3 - Journal article

VL - 28

SP - 325

EP - 333

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 4

ER -

ID: 216915481