Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction

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Fluorine-18 possesses outstanding decay characteristics for positron emission tomography (PET) imaging. Therefore, it is ideally suited for clinical applications. As such, improved strategies to incorporate fluorine-18 into bioactive molecules are of utmost importance. Indirect 18 F-labeling with amino-functionalized synthons is a convenient and versatile approach to synthesize a broad variety of PET tracers. Herein, we report a method to convert 18 F-labeled azides to primary amines by means of the Staudinger reduction. Aliphatic and aromatic 18 F-labeled azides were converted into the corresponding amines with high conversion yields. The method was easily automated. From a broader perspective, the applied strategy results in two useful synthons from a single precursor and thus increases the flexibility to label diverse chemical scaffolds with minimal synthetic effort.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
ISSN1434-193X
DOIs
Publication statusAccepted/In press - 1 Jan 2019

    Research areas

  • Amines, Azides, Fluorine, Radiochemistry, Reduction

ID: 214298045