Convergent synthesis of 6-substituted phenanthridines via anionic ring closure
Research output: Contribution to journal › Journal article › Research › peer-review
M. Lysén, Jesper Langgaard Kristensen, P. Vedsø, M. Begtrup
Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and sterically nondemanding lithium amides reacted at -78 °C to produce the 6-substituted phenanthridines in 82-98% yield upon warming to room temperature. The addition of the corresponding Grignard reagents requires an excess of the organometallic reagent and extented reaction times at elevated temperature.
|Number of pages||3|
|Publication status||Published - 1 Jan 2002|