Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

Research output: Contribution to journalJournal articleResearchpeer-review

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Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. / Jensen, Heidi Dorthe; Struve, Carsten; Christensen, Søren Brøgger; Krogfelt, Karen Angeliki.

In: Frontiers in Microbiology, Vol. 8, 542, 04.04.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, HD, Struve, C, Christensen, SB & Krogfelt, KA 2017, 'Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection', Frontiers in Microbiology, vol. 8, 542. https://doi.org/10.3389/fmicb.2017.00542

APA

Jensen, H. D., Struve, C., Christensen, S. B., & Krogfelt, K. A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Frontiers in Microbiology, 8, [542]. https://doi.org/10.3389/fmicb.2017.00542

Vancouver

Jensen HD, Struve C, Christensen SB, Krogfelt KA. Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Frontiers in Microbiology. 2017 Apr 4;8. 542. https://doi.org/10.3389/fmicb.2017.00542

Author

Jensen, Heidi Dorthe ; Struve, Carsten ; Christensen, Søren Brøgger ; Krogfelt, Karen Angeliki. / Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. In: Frontiers in Microbiology. 2017 ; Vol. 8.

Bibtex

@article{cd7c85c9061747fdb41df58df8028a1b,
title = "Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection",
abstract = "The antibacterial effect of cranberry juice and the organic acids therein on infection by uro28 pathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually. The four organic acids also decreased bacterial levels in the bladder when administered together (P < 0.001), and so did the combination of malic plus citric acid (P < 0.01) and malic plus quinic acid (P < 0.05). The other tested combinations of the organic acids, and the acids administered singly, did not have any effect in the UTI model. Apparently, the antibacterial effect of the organic acids from cranberry juice on UTI can be obtained by administering a combination of malic acid and either citric or quinic acid. This study show for the first time that cranberry juice reduce E. coli colonization of the bladder in an experimental mouse model of urinary tract infection and that the organic acids are active agents.",
keywords = "Faculty of Health and Medical Sciences, Cranberry, E. coli, Vaccinium, Urinary tract infection, Malic acid, Citric Acid, quinic acid",
author = "Jensen, {Heidi Dorthe} and Carsten Struve and Christensen, {S{\o}ren Br{\o}gger} and Krogfelt, {Karen Angeliki}",
year = "2017",
month = "4",
day = "4",
doi = "10.3389/fmicb.2017.00542",
language = "English",
volume = "8",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

AU - Jensen, Heidi Dorthe

AU - Struve, Carsten

AU - Christensen, Søren Brøgger

AU - Krogfelt, Karen Angeliki

PY - 2017/4/4

Y1 - 2017/4/4

N2 - The antibacterial effect of cranberry juice and the organic acids therein on infection by uro28 pathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually. The four organic acids also decreased bacterial levels in the bladder when administered together (P < 0.001), and so did the combination of malic plus citric acid (P < 0.01) and malic plus quinic acid (P < 0.05). The other tested combinations of the organic acids, and the acids administered singly, did not have any effect in the UTI model. Apparently, the antibacterial effect of the organic acids from cranberry juice on UTI can be obtained by administering a combination of malic acid and either citric or quinic acid. This study show for the first time that cranberry juice reduce E. coli colonization of the bladder in an experimental mouse model of urinary tract infection and that the organic acids are active agents.

AB - The antibacterial effect of cranberry juice and the organic acids therein on infection by uro28 pathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually. The four organic acids also decreased bacterial levels in the bladder when administered together (P < 0.001), and so did the combination of malic plus citric acid (P < 0.01) and malic plus quinic acid (P < 0.05). The other tested combinations of the organic acids, and the acids administered singly, did not have any effect in the UTI model. Apparently, the antibacterial effect of the organic acids from cranberry juice on UTI can be obtained by administering a combination of malic acid and either citric or quinic acid. This study show for the first time that cranberry juice reduce E. coli colonization of the bladder in an experimental mouse model of urinary tract infection and that the organic acids are active agents.

KW - Faculty of Health and Medical Sciences

KW - Cranberry

KW - E. coli

KW - Vaccinium

KW - Urinary tract infection

KW - Malic acid

KW - Citric Acid

KW - quinic acid

U2 - 10.3389/fmicb.2017.00542

DO - 10.3389/fmicb.2017.00542

M3 - Journal article

C2 - 28421045

VL - 8

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 542

ER -

ID: 174930019