Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours

Research output: Contribution to journalJournal articleResearchpeer-review

Jinmei Wang, Yazhen Wu, Steffen Heegaard, Miriam Kolko

Purpose: Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells. Methods: Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2. Results: Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma. Conclusion: Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells.
Original languageEnglish
JournalActa Ophthamologica (Online)
Pages (from-to)681-685
Number of pages4
ISSN1755-3768
Publication statusPublished - Nov 2011

ID: 20649048