Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

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Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. / Bach, Anders; Pedersen, Thomas B.; Strømgaard, Kristian.

In: MedChemComm, Vol. 7, No. 3, 2016, p. 531-536.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bach, A, Pedersen, TB & Strømgaard, K 2016, 'Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor', MedChemComm, vol. 7, no. 3, pp. 531-536. https://doi.org/10.1039/C5MD00445D

APA

Bach, A., Pedersen, T. B., & Strømgaard, K. (2016). Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. MedChemComm, 7(3), 531-536. https://doi.org/10.1039/C5MD00445D

Vancouver

Bach A, Pedersen TB, Strømgaard K. Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. MedChemComm. 2016;7(3):531-536. https://doi.org/10.1039/C5MD00445D

Author

Bach, Anders ; Pedersen, Thomas B. ; Strømgaard, Kristian. / Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. In: MedChemComm. 2016 ; Vol. 7, No. 3. pp. 531-536.

Bibtex

@article{d7bd7f64e8704d96a629304690617390,
title = "Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor",
abstract = "PSD-95 PDZ domains are biologically important and promising drug targets. Here, we discover a triazole-based peptidomimetic, 10, by ‘click chemistry’. Compound 10 inhibits the PDZ2/GluN2B interaction with affinity similar to tripeptide SAV and better than current small-molecules. Thus, 10 represents a new class of PSD-95 PDZ inhibitors.",
author = "Anders Bach and Pedersen, {Thomas B.} and Kristian Str{\o}mgaard",
year = "2016",
doi = "10.1039/C5MD00445D",
language = "English",
volume = "7",
pages = "531--536",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "3",

}

RIS

TY - JOUR

T1 - Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

AU - Bach, Anders

AU - Pedersen, Thomas B.

AU - Strømgaard, Kristian

PY - 2016

Y1 - 2016

N2 - PSD-95 PDZ domains are biologically important and promising drug targets. Here, we discover a triazole-based peptidomimetic, 10, by ‘click chemistry’. Compound 10 inhibits the PDZ2/GluN2B interaction with affinity similar to tripeptide SAV and better than current small-molecules. Thus, 10 represents a new class of PSD-95 PDZ inhibitors.

AB - PSD-95 PDZ domains are biologically important and promising drug targets. Here, we discover a triazole-based peptidomimetic, 10, by ‘click chemistry’. Compound 10 inhibits the PDZ2/GluN2B interaction with affinity similar to tripeptide SAV and better than current small-molecules. Thus, 10 represents a new class of PSD-95 PDZ inhibitors.

U2 - 10.1039/C5MD00445D

DO - 10.1039/C5MD00445D

M3 - Journal article

VL - 7

SP - 531

EP - 536

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 3

ER -

ID: 154053805