Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Research output: Contribution to journalJournal articleResearchpeer-review

Matthias Manfred Herth, Valdemar L. Andersen, Szabolcs Lehel, Jacob Madsen, Gitte Moos Knudsen, Jesper Langgaard Kristensen

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.
Original languageEnglish
JournalChemical Communications
Volume49
Pages (from-to)3805-3807
Number of pages3
ISSN1359-7345
DOIs
Publication statusPublished - 2013

ID: 45105283