Development of a Divergent Route to Erythrina Alkaloids
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Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.
|Number of pages||7|
|Publication status||Published - 3 Mar 2020|
- asymmetric allylic alkylation, decarboxylative cross coupling, Erythrina alkaloids, ring closing metathesis, spiroamine, total synthesis