Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries

Research output: Contribution to journalJournal articleResearchpeer-review

L Edvinsson, H Ahnstedt, R Larsen, Majid Sheykhzade

Calcitonin gene-related peptide (CGRP) and its receptor are widely distributed within the circulation and the mechanism behind its vasodilation not only differs from one animal species to another but is also dependent on the type and size of vessel. The present study examines the nature of CGRP-induced vasodilation, characteristics of the CGRP receptor antagonist telcagepant and localization of the key components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) of the CGRP receptor in human subcutaneous arteries.
Original languageEnglish
JournalActa Physiologica (Print)
Volume210
Issue number4
Pages (from-to)811-22
Number of pages12
ISSN1748-1708
DOIs
Publication statusPublished - Apr 2014

ID: 106213297