Does vitamin C deficiency affect cognitive development and function?
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- Does Vitamin C Deficiency Affect Cognitive Development and Function
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Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
|Number of pages||29|
|Publication status||Published - 2014|
- The Faculty of Health and Medical Sciences - vitamin C, cognition, oxidative stress, ROS, aging, development, stroke
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