Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man.

Research output: Contribution to journalJournal articleResearchpeer-review

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Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man. / Jonsson, Anna; Ladenvall, Claes; Ahluwalia, Tarun Veer Singh; Kravic, Jasmina; Krus, Ulrika; Taneera, Jalal; Isomaa, B.; Tuomi, T.; Renström, F.; Groop, L.; Lyssenko, Valeriya.

In: Diabetes, The American Diabetes Association, Vol. 62, No. 8, 04.04.2013.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jonsson, A, Ladenvall, C, Ahluwalia, TVS, Kravic, J, Krus, U, Taneera, J, Isomaa, B, Tuomi, T, Renström, F, Groop, L & Lyssenko, V 2013, 'Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man.', Diabetes, The American Diabetes Association, vol. 62, no. 8.

APA

Jonsson, A., Ladenvall, C., Ahluwalia, T. V. S., Kravic, J., Krus, U., Taneera, J., ... Lyssenko, V. (2013). Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man. Diabetes, The American Diabetes Association, 62(8).

Vancouver

Jonsson A, Ladenvall C, Ahluwalia TVS, Kravic J, Krus U, Taneera J et al. Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man. Diabetes, The American Diabetes Association. 2013 Apr 4;62(8).

Author

Jonsson, Anna ; Ladenvall, Claes ; Ahluwalia, Tarun Veer Singh ; Kravic, Jasmina ; Krus, Ulrika ; Taneera, Jalal ; Isomaa, B. ; Tuomi, T. ; Renström, F. ; Groop, L. ; Lyssenko, Valeriya. / Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man. In: Diabetes, The American Diabetes Association. 2013 ; Vol. 62, No. 8.

Bibtex

@article{8f7576cf7fc749839b1793edb1528a75,
title = "Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and {\ss}-cell Function and Insulin Action in Man.",
abstract = "Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect a-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We studied 43 SNPs in 4,654 normoglycemic participants from the Finnish population-based PPP-Botnia study. Islet function was assessed, in vivo, by measuring insulin and glucagon concentrations during OGTT, and, in vitro, by measuring glucose stimulated insulin and glucagon secretion from human pancreatic islets. Carriers of risk variants in BCL11A, HHEX, ZBED3, HNF1A, IGF1 and NOTCH2 showed elevated, while those in CRY2, IGF2BP2, TSPAN8 and KCNJ11 decreased fasting and/or 2hr glucagon concentrations in vivo. Variants in BCL11A, TSPAN8, and NOTCH2 affected glucagon secretion both in vivo and in vitro. The MTNR1B variant was a clear outlier in the relationship analysis between insulin secretion and action, as well as between insulin, glucose and glucagon. Many of the genetic variants shown to be associated with type 2 diabetes or glycemic traits also exert pleiotropic in vivo and in vitro effects on islet function.",
keywords = "Faculty of Health and Medical Sciences",
author = "Anna Jonsson and Claes Ladenvall and Ahluwalia, {Tarun Veer Singh} and Jasmina Kravic and Ulrika Krus and Jalal Taneera and B. Isomaa and T. Tuomi and F. Renstr{\"o}m and L. Groop and Valeriya Lyssenko",
year = "2013",
month = "4",
day = "4",
language = "English",
volume = "62",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "8",

}

RIS

TY - JOUR

T1 - Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on a- and ß-cell Function and Insulin Action in Man.

AU - Jonsson, Anna

AU - Ladenvall, Claes

AU - Ahluwalia, Tarun Veer Singh

AU - Kravic, Jasmina

AU - Krus, Ulrika

AU - Taneera, Jalal

AU - Isomaa, B.

AU - Tuomi, T.

AU - Renström, F.

AU - Groop, L.

AU - Lyssenko, Valeriya

PY - 2013/4/4

Y1 - 2013/4/4

N2 - Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect a-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We studied 43 SNPs in 4,654 normoglycemic participants from the Finnish population-based PPP-Botnia study. Islet function was assessed, in vivo, by measuring insulin and glucagon concentrations during OGTT, and, in vitro, by measuring glucose stimulated insulin and glucagon secretion from human pancreatic islets. Carriers of risk variants in BCL11A, HHEX, ZBED3, HNF1A, IGF1 and NOTCH2 showed elevated, while those in CRY2, IGF2BP2, TSPAN8 and KCNJ11 decreased fasting and/or 2hr glucagon concentrations in vivo. Variants in BCL11A, TSPAN8, and NOTCH2 affected glucagon secretion both in vivo and in vitro. The MTNR1B variant was a clear outlier in the relationship analysis between insulin secretion and action, as well as between insulin, glucose and glucagon. Many of the genetic variants shown to be associated with type 2 diabetes or glycemic traits also exert pleiotropic in vivo and in vitro effects on islet function.

AB - Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect a-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We studied 43 SNPs in 4,654 normoglycemic participants from the Finnish population-based PPP-Botnia study. Islet function was assessed, in vivo, by measuring insulin and glucagon concentrations during OGTT, and, in vitro, by measuring glucose stimulated insulin and glucagon secretion from human pancreatic islets. Carriers of risk variants in BCL11A, HHEX, ZBED3, HNF1A, IGF1 and NOTCH2 showed elevated, while those in CRY2, IGF2BP2, TSPAN8 and KCNJ11 decreased fasting and/or 2hr glucagon concentrations in vivo. Variants in BCL11A, TSPAN8, and NOTCH2 affected glucagon secretion both in vivo and in vitro. The MTNR1B variant was a clear outlier in the relationship analysis between insulin secretion and action, as well as between insulin, glucose and glucagon. Many of the genetic variants shown to be associated with type 2 diabetes or glycemic traits also exert pleiotropic in vivo and in vitro effects on islet function.

KW - Faculty of Health and Medical Sciences

M3 - Journal article

VL - 62

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 8

ER -

ID: 45522081