Employees – University of Copenhagen

Effect of sex in the MRMT-1 model of cancer-induced bone pain

Research output: Contribution to journalJournal articleResearchpeer-review

Documents

Sarah Falk, Tamara Al-Dihaissy, Laura Mezzanotte, Anne-Marie Heegaard

An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
Original languageEnglish
Article number445
JournalF1000Research
Volume4
Issue number445
Pages (from-to)1-18
Number of pages18
ISSN2046-1402
DOIs
Publication statusPublished - 2015

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 144411400