Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.

Research output: Contribution to journalJournal article

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Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. / Sloth, Birgitte; Holst, Jens Juul; Flint, Anne; Gregersen, Nikolaj Ture; Astrup, Arne.

In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 292, No. 4, 2006, p. E1062-E1068.

Research output: Contribution to journalJournal article

Harvard

Sloth, B, Holst, JJ, Flint, A, Gregersen, NT & Astrup, A 2006, 'Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.', American Journal of Physiology: Endocrinology and Metabolism, vol. 292, no. 4, pp. E1062-E1068. https://doi.org/10.1152/ajpendo.00450.2006

APA

Sloth, B., Holst, J. J., Flint, A., Gregersen, N. T., & Astrup, A. (2006). Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. American Journal of Physiology: Endocrinology and Metabolism, 292(4), E1062-E1068. https://doi.org/10.1152/ajpendo.00450.2006

Vancouver

Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. American Journal of Physiology: Endocrinology and Metabolism. 2006;292(4):E1062-E1068. https://doi.org/10.1152/ajpendo.00450.2006

Author

Sloth, Birgitte ; Holst, Jens Juul ; Flint, Anne ; Gregersen, Nikolaj Ture ; Astrup, Arne. / Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. In: American Journal of Physiology: Endocrinology and Metabolism. 2006 ; Vol. 292, No. 4. pp. E1062-E1068.

Bibtex

@article{7f4ca640a1c211ddb6ae000ea68e967b,
title = "Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.",
abstract = "Peptide YY (PYY)(3-36) has been shown to produce dramatic reductions in energy intake (EI), but no human data exist regarding energy expenditure (EE), glucose and fat metabolism. Nothing is known regarding PYY1-36. To compare effects of PYY(1-36) and PYY(3-36) on appetite, EI, EE, insulin, glucose and free fatty acids (FFA) concentrations, 12 lean and 12 obese males participated in a blinded, randomized, crossover study with 90-min infusions of saline, 0.8 pmol x kg(-1) x min(-1) PYY(1-36) and PYY(3-36). Only four participants completed PYY(3-36) infusions because of nausea. Subsequently, six lean and eight obese participants completed 0.2 pmol x kg(-1) x min(-1) PYY(3-36) and 1.6 pmol x kg(-1) x min(-1) PYY(1-36) infusions. PYY(3-36) [corrected] produced [corrected] lower ratings of well-being and [corrected] increases in heart rate, [corrected] FFA, and [corrected] postprandial [corrected] insulin concentrations. Furthermore, high-dose [corrected] PYY(3-36) (0.8 [corrected] pmol x kg(-1) x min(-1)) produced decreased [corrected] EI and increased postprandial [corrected] glucose concentrations and tendency to reduced EE [corrected]",
keywords = "Former LIFE faculty, PYY, appetit, energy intake, obese and lean subjects",
author = "Birgitte Sloth and Holst, {Jens Juul} and Anne Flint and Gregersen, {Nikolaj Ture} and Arne Astrup",
note = "Keywords: Adult; Appetite; Blood Glucose; Cross-Over Studies; Dose-Response Relationship, Drug; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; Heart Rate; Humans; Insulin; Lipolysis; Male; Obesity; Osmolar Concentration; Peptide YY; Postprandial Period; Thermogenesis",
year = "2006",
doi = "10.1152/ajpendo.00450.2006",
language = "English",
volume = "292",
pages = "E1062--E1068",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.

AU - Sloth, Birgitte

AU - Holst, Jens Juul

AU - Flint, Anne

AU - Gregersen, Nikolaj Ture

AU - Astrup, Arne

N1 - Keywords: Adult; Appetite; Blood Glucose; Cross-Over Studies; Dose-Response Relationship, Drug; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; Heart Rate; Humans; Insulin; Lipolysis; Male; Obesity; Osmolar Concentration; Peptide YY; Postprandial Period; Thermogenesis

PY - 2006

Y1 - 2006

N2 - Peptide YY (PYY)(3-36) has been shown to produce dramatic reductions in energy intake (EI), but no human data exist regarding energy expenditure (EE), glucose and fat metabolism. Nothing is known regarding PYY1-36. To compare effects of PYY(1-36) and PYY(3-36) on appetite, EI, EE, insulin, glucose and free fatty acids (FFA) concentrations, 12 lean and 12 obese males participated in a blinded, randomized, crossover study with 90-min infusions of saline, 0.8 pmol x kg(-1) x min(-1) PYY(1-36) and PYY(3-36). Only four participants completed PYY(3-36) infusions because of nausea. Subsequently, six lean and eight obese participants completed 0.2 pmol x kg(-1) x min(-1) PYY(3-36) and 1.6 pmol x kg(-1) x min(-1) PYY(1-36) infusions. PYY(3-36) [corrected] produced [corrected] lower ratings of well-being and [corrected] increases in heart rate, [corrected] FFA, and [corrected] postprandial [corrected] insulin concentrations. Furthermore, high-dose [corrected] PYY(3-36) (0.8 [corrected] pmol x kg(-1) x min(-1)) produced decreased [corrected] EI and increased postprandial [corrected] glucose concentrations and tendency to reduced EE [corrected]

AB - Peptide YY (PYY)(3-36) has been shown to produce dramatic reductions in energy intake (EI), but no human data exist regarding energy expenditure (EE), glucose and fat metabolism. Nothing is known regarding PYY1-36. To compare effects of PYY(1-36) and PYY(3-36) on appetite, EI, EE, insulin, glucose and free fatty acids (FFA) concentrations, 12 lean and 12 obese males participated in a blinded, randomized, crossover study with 90-min infusions of saline, 0.8 pmol x kg(-1) x min(-1) PYY(1-36) and PYY(3-36). Only four participants completed PYY(3-36) infusions because of nausea. Subsequently, six lean and eight obese participants completed 0.2 pmol x kg(-1) x min(-1) PYY(3-36) and 1.6 pmol x kg(-1) x min(-1) PYY(1-36) infusions. PYY(3-36) [corrected] produced [corrected] lower ratings of well-being and [corrected] increases in heart rate, [corrected] FFA, and [corrected] postprandial [corrected] insulin concentrations. Furthermore, high-dose [corrected] PYY(3-36) (0.8 [corrected] pmol x kg(-1) x min(-1)) produced decreased [corrected] EI and increased postprandial [corrected] glucose concentrations and tendency to reduced EE [corrected]

KW - Former LIFE faculty

KW - PYY

KW - appetit

KW - energy intake

KW - obese and lean subjects

U2 - 10.1152/ajpendo.00450.2006

DO - 10.1152/ajpendo.00450.2006

M3 - Journal article

VL - 292

SP - E1062-E1068

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 4

ER -

ID: 8072580