Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test

Research output: Contribution to journalJournal articleResearchpeer-review

Louise Konradsen Refsgaard, Kia Haubro, Darryl S Pickering, Sarah Stuart, Emma Robinson, Jesper Andreasen T.

Rationale
Affective biases seemingly play a crucial role for the onset and development of depression. Acute treatment with monoamine-based antidepressants positively influence emotional processing, and an early correction of biases likely results in repeated positive experiences that ultimately lead to improved mood.

Objectives
Using two conventional antidepressants, sertraline and duloxetine, we aimed to forward the characterization of a newly developed affective bias test (ABT) for rats. Further, we examined the effect of vortioxetine, a recently approved antidepressant, and the α2 adrenoceptor antagonist idazoxan on
affective biases.
Original languageEnglish
JournalPsychopharmacology
Volume233
Issue number21
Pages (from-to)3763-3770
Number of pages8
ISSN0033-3158
DOIs
Publication statusPublished - 14 Oct 2016

ID: 164572514