Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda

Research output: Contribution to journalJournal articleResearchpeer-review

Harriet Namwanje, Narcis B. Kabatereine, Annette Olsen

A randomised clinical trial was conducted in Kabale District, southwestern Uganda, to compare the efficacies of single and double doses of a combination of 400mg albendazole (ALB) and 500mg mebendazole (MBZ) with those of single and double doses of each drug given alone in the treatment of Trichuris trichiura. Infected pupils (n=611) were randomised to six treatment groups. Three groups received either a single dose of ALB, MBZ or the combination (ALB+MBZ). The other three groups received either a double dose of ALB (ALB/ALB), MBZ (MBZ/MBZ) or the combination (ALB+MBZ/ALB+MBZ). All double doses were given 8h apart. Children were followed-up weekly for 1 month. Cure rates were significantly higher using double doses compared with single doses (irrespective of drug; z=-4.02, P
Original languageEnglish
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume105
Issue number10
Pages (from-to)586-590
Number of pages5
ISSN0035-9203
DOIs
Publication statusPublished - 2011

ID: 35056163