First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization

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Daniel Yohannes, Camilla Petrycer Hansen, Srinivasa Rao Akireddy, Terry A Hauser, Melanie N Kiser, Nicholas J Gurnon, Cynthia S Day, Balwinder Bhatti, William S Caldwell

The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
Original languageEnglish
JournalOrganic Letters
Issue number23
Pages (from-to)5353-5356
Publication statusPublished - 2008

ID: 10162587