First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization

Research output: Contribution to journalJournal articleResearchpeer-review

  • Daniel Yohannes
  • Camilla Petrycer Hansen
  • Srinivasa Rao Akireddy
  • Terry A Hauser
  • Melanie N Kiser
  • Nicholas J Gurnon
  • Cynthia S Day
  • Balwinder Bhatti
  • William S Caldwell
The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
Original languageEnglish
JournalOrganic Letters
Issue number23
Pages (from-to)5353-5356
Publication statusPublished - 2008

ID: 10162587